MSP-1 Activators
MSP-1 Activators are thought to exert their effects through the modulation of intracellular signaling pathways. Forskolin and isoproterenol act to elevate cAMP levels, triggering PKA activation. Since PKA mediates phosphorylation events that can modify protein activity, these compounds might enhance MSP-1 activation as PKA phosphorylation is involved in its regulation. Anisomycin and TPA are known to activate JNK/SAPK and PKC pathways, respectively, which could lead to the activation of MSP-1 through stress and inflammatory response pathways or through direct phosphorylation as MSP-1 is a PKC substrate.
The increase in intracellular calcium by ionomycin and A23187 can act on various calcium-dependent signaling molecules, potentially including MSP-1 as it is responsive to calcium signaling. The use of cAMP analogs such as 8-Br-cAMP and db-cAMP can mimic the effect of cAMP elevation, directly activating cAMP-dependent pathways and potentially affecting the activation status of MSP-1. Epinephrine, as a physiological activator of adrenergic receptors, can also stimulate cAMP production and activate these pathways. Thapsigargin's role in manipulating calcium signaling can influence numerous calcium-dependent proteins and pathways, with potential effects on MSP-1. Lastly, retinoic acid modulates gene expression and could affect MSP-1.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, leading to an increase in cAMP levels and subsequent activation of PKA. If MSP-1 activity is modulated by PKA, forskolin can enhance its activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Beta-adrenergic agonist that stimulates the production of cAMP by activating adrenergic receptors, potentially promoting the activation of downstream proteins like MSP-1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
A pyrrolidine antibiotic that acts as a potent activator of the JNK/SAPK pathway by inducing stress-activated protein kinases, potentially affecting MSP-1 if part of this response. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
An analogue of PMA that activates PKC. PKC can influence numerous signaling cascades and might activate MSP-1 if PKC is a part of its regulatory mechanism. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, leading to the activation of calcium-dependent proteins and possibly affecting MSP-1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diester of phorbol that activates PKC, which might enhance the activation of MSP-1 directly or through PKC-mediated pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore which, like ionomycin, increases intracellular calcium and activates calcium-dependent proteins, potentially including MSP-1. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
A cAMP analog that activates cAMP-dependent pathways, potentially enhancing the activation of MSP-1 if it is under cAMP-dependent control. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Also known as adrenaline, it activates adrenergic receptors leading to increased cAMP and activation of cAMP-dependent pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that directly stimulates cAMP-dependent pathways, potentially activating MSP-1 if it's regulated by these pathways. | ||||||