MRP-S33 Activators
MRP-S33 Activators are a diverse array of chemical compounds that indirectly stimulate the functional activity of MRP-S33 through their influence on various intracellular signaling pathways. Forskolin, through catalyzing the conversion of ATP to cAMP, indirectly boosts MRP-S33's activity by increasing PKA activity, which can result in the phosphorylation and activation of MRP-S33. Similarly, PMA, by activating PKC, may modulate the phosphorylation status of MRP-S33, leading to its enhanced activity. Sphingosine-1-phosphate, by binding to its receptors, triggers PI3K/Akt signaling pathways that could potentiate MRP-S33 activity, whereasIonomycin, by elevating intracellular calcium, could activate calmodulin-dependent kinases that enhance MRP-S33 through calcium-dependent signaling. Additionally, Epigallocatechin gallate (EGCG) may facilitate the activation of this protein by inhibiting kinases that negatively regulate pathways involving MRP-S33, thus lifting their inhibitory effect and promoting MRP-S33's role in the cell.
The biochemical landscape governing MRP-S33 activity is further shaped by LY294002 and U73122, which influence PI3K and PLC pathways, respectively; these compounds may augment MRP-S33 activity through alterations in downstream signaling. Similarly, the calcium ionophore A23187 could potentiate MRP-S33's activation by enhancing calcium-dependent pathways. Cyclic AMP analogs such as Dibutyryl-cAMP (db-cAMP) and 8-Bromo-cAMP, which activate PKA, could also enhance MRP-S33 activity through phosphorylation mechanisms. Moreover, Anisomycin might activate stress-activated protein kinases that lead to the activation of MRP-S33 as part of the cellular stress response. Finally, Okadaic acid, by inhibiting protein phosphatases, may result in the enhanced phosphorylation of MRP-S33, thus facilitating its activation within the cell. Collectively, these compounds advance the functional capacity of MRP-S33 through a network of signaling pathways that converge on the regulation of this protein's phosphorylation and activity status.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate and enhance the activity of MRP-S33, thereby promoting its functional role in cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC has been shown to phosphorylate related proteins and could enhance the activation of MRP-S33 by modulating its phosphorylation status directly or through downstream signaling mechanisms. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) interacts with its G protein-coupled receptors to activate downstream signaling cascades, such as PI3K/Akt. This can increase the activity of MRP-S33 by modulating cellular survival and proliferation pathways in which MRP-S33 is implicated. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinases, which could then enhance the activity of MRP-S33 through calcium-dependent signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that inhibits certain types of kinases. By inhibiting competitive kinases, EGCG may enhance signaling pathways that lead to the activation of MRP-S33, particularly if MRP-S33 is negatively regulated by these kinases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, LY294002 can alter downstream signaling pathways such as Akt, potentially resulting in the activation of MRP-S33 if it is involved in these pathways or if there's a negative feedback loop that enhances MRP-S33's activity when PI3K is inhibited. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore like Ionomycin and similarly increases intracellular calcium levels, which could potentiate the activation of MRP-S33 through calcium-dependent signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a membrane-permeable analog of cAMP, which activates PKA. Activation of PKA is known to phosphorylate various proteins and could enhance the activity of MRP-S33 if it is a substrate for PKA or is involved in cAMP/PKA signaling pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is another analog of cAMP that activates PKA. The enhancement of PKA activity can lead to the phosphorylation and activation of MRP-S33, assuming MRP-S33 is involved in cAMP-dependent signaling. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs). Activation of SAPKs could lead to the enhanced activation of MRP-S33 if MRP-S33 is involved in cellular stress response pathways. | ||||||