MRP-S24 Activators
MRP-S24 activators refer to a class of chemical compounds that are specifically designed to modulate the activity of a molecular entity known as MRP-S24, which is a designation for a protein or a group of proteins involved in various cellular processes. The nature of the interaction between MRP-S24 activators and the proteins they target can vary significantly, encompassing direct binding to the active site, allosteric modulation where the binding occurs at a site distinct from the active site, or by influencing the protein's expression, stability, and processing within the cell.
The chemical structure of MRP-S24 activators is diverse, reflecting the breadth of strategies employed to enhance the function of MRP-S24. These activators are often the result of extensive medicinal chemistry efforts that involve the synthesis and modification of molecular scaffolds to optimize their interaction with the protein. The design of such molecules is typically informed by a detailed understanding of the protein's structure and the regulatory mechanisms governing its activity. High-throughput screening methods, computational modelling, and structure-activity relationship (SAR) studies are common tools used in the development of MRP-S24 activators. These compounds must possess certain pharmacokinetic properties that enable them to reach their target within the biological system and engage with the protein in a manner that leads to an increase in its activity. The precise biochemical pathways through which MRP-S24 activators exert their modulatory effects can be complex and may involve the alteration of downstream signaling cascades, protein-protein interactions, or transcriptional and translational processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin enhances the activity of adenylate cyclase, which increases the levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate and thus activate target proteins, including MRP-S24, enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC leads to phosphorylation of certain serine/threonine residues on target proteins. MRP-S24, if it has potential PKC phosphorylation sites, would have its activity enhanced through this pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations, which activates calcium-dependent protein kinases, potentially leading to the phosphorylation and activation of MRP-S24. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that activates adenylate cyclase, leading to increased cAMP production. This in turn activates PKA, which may phosphorylate and enhance the activity of MRP-S24. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cAMP analog that activates PKA. By bypassing the adenylate cyclase step, it directly activates PKA, leading to the phosphorylation of target proteins, including potentially MRP-S24. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases intracellular levels of cAMP by preventing its degradation. The resulting activation of PKA could lead to increased functional activity of MRP-S24. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases such as JNK. Activation of these kinases could enhance the phosphorylation and activity of MRP-S24. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is another cAMP analog that is resistant to degradation by phosphodiesterases, leading to sustained PKA activation. This could result in prolonged phosphorylation and activation of MRP-S24. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that, similar to Ionomycin, increases intracellular calcium levels and activates calcium-dependent kinases, which may phosphorylate and enhance the activity of MRP-S24. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which leads to increased phosphorylation levels of proteins within the cell. This could result in the enhancement of MRP-S24 activity if it is subject to dephosphorylation regulation. | ||||||