Date published: 2026-4-1

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MRP-L45 Inhibitors

MRP-L45 inhibitors belong to a specific chemical class that targets the MRP-L45 protein. This protein is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in cellular transport processes. The MRP-L45 protein is responsible for the translocation of various substrates across cell membranes, including drugs, toxins, and endogenous compounds. By inhibiting the activity of MRP-L45, these inhibitors can modulate the efflux of substrates, potentially impacting cellular homeostasis and altering disposition. The chemical structure of MRP-L45 inhibitors is diverse, typically comprising small organic molecules. These compounds possess specific functional groups and 3D arrangements that facilitate their interaction with the active site of the MRP-L45 protein. The inhibition of MRP-L45 could potentially affect resistance mechanisms in various diseases, as it could impede the efflux of agents, increasing their intracellular concentrations. Research on MRP-L45 inhibitors is an active area of investigation.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Probenecid

57-66-9sc-202773
sc-202773A
sc-202773B
sc-202773C
1 g
5 g
25 g
100 g
$28.00
$39.00
$100.00
$277.00
28
(2)

A uricosuric agent that inhibits various MRP transporters, including MRP1 and MRP2.

MK-571

115103-85-0sc-201340
sc-201340A
5 mg
25 mg
$109.00
$421.00
8
(2)

A selective inhibitor of MRP1 and MRP2 transporters.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

A flavonoid found in many fruits and vegetables, known to inhibit several MRP transporters.

Reversan

313397-13-6sc-296262
sc-296262A
10 mg
50 mg
$185.00
$781.00
3
(0)

A synthetic compound that inhibits MRP1 and P-glycoprotein (P-gp).

Cepharanthine

481-49-2sc-391213
sc-391213A
100 mg
500 mg
$45.00
$150.00
2
(0)

An alkaloid that inhibits MRP1 and MRP2 transporters.

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$29.00
$38.00
18
(1)

Indomethacin (CAS 53-86-1) functions as an inhibitor of the MRP-L45 protein, a component of the mitochondrial ribosome. Its inhibitory action involves interference with the protein′s role in mitochondrial translation, affecting protein synthesis. Researchers studying mitochondrial biology and protein function utilize indomethacin to explore mechanisms regulating mitochondrial activity and protein interactions within the ribosomal complex.

Benzbromarone

3562-84-3sc-233934
sc-233934A
1 g
5 g
$53.00
$223.00
(1)

A uricosuric agent that inhibits MRP4 and MRP2.

Erythromycin

114-07-8sc-204742
sc-204742A
sc-204742B
sc-204742C
5 g
25 g
100 g
1 kg
$57.00
$245.00
$831.00
$1331.00
4
(3)

An antibiotic that can inhibit MRP2.

Sulfasalazine

599-79-1sc-204312
sc-204312A
sc-204312B
sc-204312C
1 g
2.5 g
5 g
10 g
$61.00
$77.00
$128.00
$209.00
8
(1)

Sulfasalazine (CAS 599-79-1) is a compound known for its role as an inhibitor of the mitochondrial ribosomal protein L45 (MRP-L45). It functions by disrupting the activity of this protein, which is involved in the mitochondrial translation process. Through this inhibition, Sulfasalazine affects protein synthesis within the mitochondria, providing valuable insights into the regulatory mechanisms of mitochondrial function in scientific research.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

Cyclosporin A (CAS 59865-13-3) is a potent inhibitor of the mitochondrial ribosomal protein L45 (MRP-L45). It disrupts MRP-L45 function by interfering with its ability to facilitate protein synthesis within the mitochondrial ribosome. This interaction can be used in research to study mitochondrial ribosomal dynamics and protein translation, aiding in the understanding of mitochondrial biology and related processes.