Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (Mdr-1) and P-glycoprotein (P-gp). Increases the sensitivity of Mdr-1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively
Burkhart et al (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69 6573.
Soluble in DMSO (25 mM), ethanol (5 mM), and chloroform.
Store at room temperature
~1.26 g/cm3 (Predicted)
n20D ~1.66 (Predicted)
pKa: 11.33 (Predicted), pKb: 7.12 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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