Reversan CAS: 313397-13-6
MF: C26H27N5O2
MW: 441.52
Selective inhibitor of Mdr-1 that increases efficacy of etoposide in murine models of neuroblastoma.

Reversan (CAS 313397-13-6)

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Alternate Names: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Application: Reversan is selective inhibitor of Mdr-1 that increases efficacy of etoposide in murine models of neuroblastoma
CAS Number: 313397-13-6
Molecular Weight: 441.52
Molecular Formula: C26H27N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (Mdr-1) and P-glycoprotein (P-gp). Increases the sensitivity of Mdr-1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively


References

Burkhart et al (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69 6573.

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM), ethanol (5 mM), and chloroform.
Storage :
Store at room temperature
Melting Point :
176-180° C
Density :
~1.26 g/cm3 (Predicted)
Refractive Index :
n20D ~1.66 (Predicted)
pK Values :
pKa: 11.33 (Predicted), pKb: 7.12 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
2298706
MDL Number :
MFCD01528184
SMILES :
C1COCCN1CCCNC(=O)C2=C3N=C(C=C(N3N=C2)C4=CC=CC=C4)C5=CC=CC=C5

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Certificate of Analysis

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Reversan (CAS 313397-13-6)  Product Citations

See how others have used Reversan (CAS 313397-13-6). Click on the entry to view the PubMed entry .

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PMID: # 30150787  Sci Rep. 8: 12920.

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