Molecular structure of Reversan, CAS Number: 313397-13-6
Reversan (CAS 313397-13-6)
See product citations (3)
Alternate Names:
N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Application:
Reversan is selective inhibitor of Mdr-1 that increases efficacy of etoposide in murine models of neuroblastoma
CAS Number:
313397-13-6
Molecular Weight:
441.52
Molecular Formula:
C26H27N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (Mdr-1) and P-glycoprotein (P-gp). It increases the sensitivity of Mdr-1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine, and etoposide by 3.8-, 14.6- and 11.6-fold, respectively. Reversan has also been found to be an effective inhibitor of the cytochrome P450 enzyme system, which is involved in metabolism. Moreover, it can inhibit the growth of various types of bacteria.
Reversan (CAS 313397-13-6) References
- Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. | Burkhart, CA., et al. 2009. Cancer Res. 69: 6573-80. PMID: 19654298
- An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1. | Helms, HC., et al. 2014. AAPS J. 16: 1046-55. PMID: 24934296
- Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. | Tivnan, A., et al. 2015. Front Neurosci. 9: 218. PMID: 26136652
- Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization. | Obreque-Balboa, JE., et al. 2016. Eur J Med Chem. 109: 124-33. PMID: 26774038
- NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels. | Wen, X., et al. 2019. FEBS J. 286: 678-687. PMID: 30653821
- γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. | Corti, A., et al. 2019. Sci Rep. 9: 891. PMID: 30696905
- Suppression of Proliferation of Human Glioblastoma Cells by Combined Phosphodiesterase and Multidrug Resistance-Associated Protein 1 Inhibition. | Kopanitsa, L., et al. 2021. Int J Mol Sci. 22: PMID: 34575827
- Synthesis of structural analogues of Reversan by ester aminolysis: an access to pyrazolo[1,5-a]pyrimidines from chalcones. | Arias-Gómez, A., et al. 2023. RSC Adv. 13: 16377-16386. PMID: 37266500
Inhibitor of:
Mdr-1, and MRP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reversan, 10 mg | sc-296262 | 10 mg | $185.00 | |||
Reversan, 50 mg | sc-296262A | 50 mg | $781.00 |