MRP-L43 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressive agent that inhibits calcineurin. By inhibiting calcineurin, it prevents the dephosphorylation and activation of nuclear factor of activated T-cells (NFAT), a transcription factor. This leads to the downregulation of cytokines and other genes that could be upregulated by MRP-L43, thus indirectly decreasing MRP-L43 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that impedes the mTORC1 complex, which is crucial for protein synthesis and cell growth. As MRP-L43 is involved in mitochondrial protein translation, rapamycin can indirectly lead to reduced expression of MRP-L43 by limiting protein synthesis capacity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that impedes the PI3K/AKT/mTOR signaling pathway. This inhibition can downregulate protein synthesis and cell growth, indirectly affecting MRP-L43 function by reducing the resources and signals needed for its expression and activity. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Spironolactone is an aldosterone antagonist with secondary inhibition of androgen receptors. It can indirectly decrease MRP-L43 activity by altering mitochondrial function and biogenesis, which are partially regulated by androgen signaling. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin is an inhibitor of ATP synthase in mitochondrial electron transport. By reducing the mitochondrial membrane potential and ATP production, it can indirectly affect the functional activity of MRP-L43, which is involved in mitochondrial protein synthesis. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A inhibits the mitochondrial electron transport chain at complex III. This leads to a reduction in ATP production and disrupts mitochondrial function, potentially decreasing MRP-L43 activity due to energy deficits. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. Inhibition of complex I disrupts oxidative phosphorylation, leading to decreased ATP production and mitochondrial dysfunction, which can indirectly reduce MRP-L43 activity. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol is an antibiotic that inhibits bacterial protein synthesis. It can also affect mitochondrial ribosomes due to their bacterial evolutionary origin, potentially decreasing MRP-L43 function by inhibiting mitochondrial protein translation. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $170.00 $385.00 | 3 | |
Actinonin is a peptide deformylase inhibitor that can impede mitochondrial protein maturation. By inhibiting this process, actinonin may indirectly decrease MRP-L43 activity by affecting the processing of mitochondrial proteins that MRP-L43 may help translate. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation in the ER. While not directly affecting mitochondrial proteins, it can cause global protein synthesis stress and a UPR in the ER, which can indirectly impact mitochondrial function and potentially decrease MRP-L43 activity. | ||||||