Date published: 2025-9-10

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MRP-L43 Inhibitors

MRP-L43 Inhibitors belong to a specialized class of chemical compounds that play a crucial role in modulating cellular processes. MRP-L43 is a specific protein, and inhibitors targeting this protein are designed to impede its activity. The MRP-L43 protein, also known as Multidrug Resistance-associated Protein-L43, is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC transporters are integral membrane proteins involved in the transport of various substrates across cellular membranes, utilizing energy found in the hydrolysis of ATP. MRP-L43, in particular, is implicated in the efflux of diverse molecules from the cell, contributing to cellular homeostasis and defense mechanisms. The inhibitors of MRP-L43 are characterized by their ability to selectively bind to the protein, disrupting its function and, consequently, modulating the transport of substrates. The development of these inhibitors is rooted in a deeper understanding of the molecular mechanisms underlying cellular transport processes. Researchers aim to decipher the intricate interplay between MRP-L43 and its substrates to design molecules that can selectively inhibit its activity. This class of chemical compounds represents a promising avenue for further research into cellular transport mechanisms and has the potential to shed light on novel strategies for manipulating cellular processes at the molecular level. As scientists continue to unravel the intricacies of MRP-L43 inhibition, this chemical class holds significance in advancing our understanding of cellular biology and may pave the way for innovative approaches in various scientific domains.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$173.00
$418.00
43
(3)

Doxorubicin is known to generate reactive oxygen species and intercalate DNA, leading to cytotoxicity. This can indirectly decrease MRP-L43 activity by causing mitochondrial damage and dysfunction, thus affecting MRP-L43's role in mitochondrial protein synthesis.