MRP-L16 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A, a calcineurin inhibitor, disrupts mitochondrial function by inhibiting the calcium/calmodulin-dependent protein phosphatase calcineurin. Inhibition of this pathway can reduce the import of mitochondrial proteins, including MRP-L16, due to impaired mitochondrial membrane potential. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $118.00 $337.00 $520.00 $832.00 $1632.00 | 10 | |
ABT-199, a BCL-2 inhibitor, induces mitochondrial outer membrane permeabilization, leading to the release of cytochrome c. This process disrupts the mitochondrial integrity, which can indirectly decrease the stability and incorporation of MRP-L16 into the mitochondrial ribosome. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin binds to the OSCP subunit of ATP synthase, inhibiting ATP synthesis. This inhibition causes a buildup of ADP and subsequent downregulation of mitochondrial protein synthesis, indirectly affecting MRP-L16's integration into the mitochondrial ribosome. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A binds to the Q_i site of complex III in the mitochondrial electron transport chain, inhibiting electron transfer and reducing ATP synthesis. The resulting energy depletion can inhibit the incorporation of MRP-L16 into the mitochondrial ribosome due to reduced mitochondrial translation. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP uncouples oxidative phosphorylation by transporting protons across the mitochondrial membrane, dissipating the proton gradient. This leads to a decrease in ATP production, limiting the energy-dependent process of MRP-L16 integration into mitochondrial ribosomes. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone inhibits the transfer of electrons from iron-sulfur centers in complex I to ubiquinone, disrupting ATP synthesis. Reduced ATP levels can hinder MRP-L16's assembly into the mitochondrial ribosome as this process is energy-dependent. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline binds to the 30S subunit of bacterial ribosomes and can similarly affect mitochondrial ribosomes due to their bacterial origin. This binding may inhibit MRP-L16 incorporation by disrupting ribosome assembly. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit and may indirectly inhibit mitochondrial protein synthesis, impacting the assembly of MRP-L16 into the mitochondrial ribosome. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $170.00 $385.00 | 3 | |
Actinonin is a peptide deformylase inhibitor, which can affect the N-terminal processing of nascent proteins destined for the mitochondria, potentially hindering the proper folding and integration of MRP-L16 into the mitochondrial ribosome. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, reducing mRNA synthesis in the nucleus. This reduction in mRNA levels can indirectly affect the translation of mitochondrial-encoded proteins, potentially impacting the functional activity of MRP-L16. | ||||||