MrgA5 Inhibitors
MrgA5 inhibitors are a class of chemicals that interact with the signaling pathways and cellular processes related to the activity of the MAS-related GPR, member A5 protein, a G protein-coupled receptor (GPCR). These inhibitors are not specific to MrgA5 itself but influence the protein's activity by modulating the GPCR signaling pathway that MrgA5 is a part of or by affecting related cellular processes.
The chemical class of MrgA5 inhibitors encompasses a diverse range of compounds. Caffeine and clozapine, for example, act as antagonists at adenosine receptors and various GPCRs, respectively, with the potential to alter the activity of MrgA5. Pertussis and cholera toxins exert their effects by irreversibly modifying G proteins, which play a pivotal role in GPCR signaling. Phospholipase C and phosphoinositide 3-kinase inhibitors like U73122, wortmannin, and LY294002 can interfere with the downstream signaling cascade of GPCRs. Compounds such as L-NAME and methylene blue influence the production or activity of secondary messengers like nitric oxide and cGMP, which are part of the GPCR signaling network. Forskolin, by directly activating adenylyl cyclase, elevates cAMP levels and thereby has the capacity to modulate GPCR-mediated signaling pathways. Each of these compounds can impact the function of MrgA5 by altering the signaling environment in which MrgA5 operates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine acts as an antagonist at adenosine receptors, which can modulate GPCR signaling, including potentially influencing the activity of MrgA5. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases, which are involved in various signaling pathways including those linked to GPCRs. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis toxin irreversibly modifies G proteins, thereby potentially affecting MrgA5-related signaling pathways. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
L-NAME is a nitric oxide synthase inhibitor, which can modulate GPCR signaling indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another inhibitor of phosphoinositide 3-kinases, like Wortmannin, affecting signaling pathways involving GPCRs. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A | 50 mg 500 mg | $68.00 $357.00 | 11 | |
Clozapine is an antagonist of various GPCRs and could thus potentially alter MrgA5 signaling. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is a polysulfonated naphthylurea that inhibits various G protein-related enzymes and receptors, potentially impacting GPCR signaling. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Methylene Blue inhibits guanylate cyclase, which is part of the signaling pathway of some GPCRs. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, which can change the level of cAMP in cells and thus modulate GPCR signaling pathways. | ||||||