MPP1 Activators
MPP1 Activators are diverse chemical compounds that enhance the functional activity of MPP1 through distinct signaling pathways and molecular mechanisms. Forskolin, by raising intracellular cAMP levels, activates PKA, which may phosphorylate MPP1 or its associated proteins, thereby enhancing MPP1's cellular roles, particularly in cytoskeletal organization and cell signaling. Similarly, PMA, as a PKC activator, can initiate a signaling cascade resulting in the phosphorylation of MPP1 or proteins within its pathway, leading to an increase in MPP1 activity and its ability to maintain cell integrity. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent kinases that may target MPP1 or its associated proteins, resulting in enhanced MPP1 activity within the cell.
Further, the lipid signaling molecule Sphingosine-1-phosphate activates G-protein coupled receptors, which may lead to downstream effects that enhance MPP1 activity. Genistein, through its tyrosine kinase inhibitory action, could relieve negative regulatory effects on MPP1, thereby indirectly promoting MPP1's role in signal transduction. EGCG, LY294002, and Wortmannin, by inhibiting various kinases and the PI3K pathway, may decrease negative feedback on pathways that enhance MPP1 activity. U0126 and SB203580, which target MEK1/2 and p38 MAPK respectively, potentially shift signaling equilibria to favor pathways that enhance MPP1. Lastly, Thapsigargin and A23187, by increasing intracellular calcium levels, activate calcium-dependent signaling pathways that can indirectly lead to the enhancement of MPP1 functions, emphasizing the importance of calcium signaling in regulating MPP1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, thereby increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate MPP1 or associated regulatory proteins, enhancing MPP1's cellular functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as a potent PKC activator, which in turn can activate signaling pathways that lead to the phosphorylation and subsequent activation of MPP1, thereby augmenting its role in cell signaling and structure. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin functions as a calcium ionophore, elevating intracellular Ca²⁺ levels. This can activate Ca²⁺-dependent protein kinases, which may lead to the phosphorylation and enhancement of MPP1 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can activate G-protein coupled receptors which influence downstream effectors that can modify MPP1 activity, thus indirectly enhancing MPP1's role in cell structure and signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor with broad specificity. By inhibiting certain kinases, EGCG could reduce negative regulation on MPP1, leading to its indirect activation and enhancement of its cellular functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which by inhibiting PI3K can reduce Akt phosphorylation and activity. This may relieve negative feedback on certain pathways, potentially allowing for indirect enhancement of MPP1's activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
As another PI3K inhibitor, Wortmannin may similarly lead to increased activity of pathways that could indirectly enhance the function of MPP1 by reducing competitive signaling that might otherwise suppress MPP1 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This p38 MAPK inhibitor may shift signaling in favor of pathways that enhance MPP1 activity by reducing the inhibitory phosphorylation events that would otherwise dampen MPP1 function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that could liberate MPP1 from negative tyrosine kinase mediated regulation, potentially enhancing MPP1's role in cellular processes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor leading to increased cytosolic calcium levels. This rise in calcium could activate pathways that indirectly increase the activity of MPP1. | ||||||