MKLP-1 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ro-31-8220 in solution | 138489-18-6 | sc-358721 | 1 mg | $104.00 | 2 | |
Ro-31-8220 is a broad-spectrum inhibitor of protein kinases, particularly PKC isoforms. It competes with ATP to inhibit the catalytic activity of these kinases, impacting various signaling pathways and cellular processes. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts mitotic spindle formation, leading to cell cycle arrest. Its action suggests potential indirect effects on MKLP-1 by altering spindle dynamics and possibly cytokinesis. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
A potent inhibitor of kinesin Eg5, S-Trityl-L-cysteine disrupts mitotic spindle assembly. This disruption could indirectly influence MKLP-1 function by affecting spindle apparatus components and mitotic progression. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
Primarily a Plk1 inhibitor, BI-2536's action leads to mitotic arrest. While not directly inhibiting MKLP-1, it affects the overall mitotic process and spindle assembly, potentially impacting MKLP-1's activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor, ZM447439 inhibits Aurora A and B kinases, affecting chromosome alignment and segregation. This inhibition can indirectly affect MKLP-1 by altering the kinases that regulate cytokinesis and spindle dynamics. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Targeting Aurora A kinase, MLN8237 disrupts mitotic processes. Its impact on the regulatory pathways of mitosis might indirectly influence MKLP-1 function, given the interconnectedness of mitotic regulation. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
A cyclin-dependent kinase inhibitor, Purvalanol A blocks cell cycle progression. This blockade indirectly affects MKLP-1 by impacting the cell cycle regulators that control mitotic entry and progression. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $61.00 $85.00 | 4 | |
Inhibiting Aurora kinases, Tozasertib affects chromosome alignment and mitotic exit. These changes can indirectly influence MKLP-1 function by modifying the kinases that oversee cytokinesis, possibly affecting MKLP-1's role. | ||||||
AZ 3146 | 1124329-14-1 | sc-361114 sc-361114A | 10 mg 50 mg | $214.00 $887.00 | 7 | |
A Mps1/TTK inhibitor, AZ3146 affects spindle assembly checkpoint, leading to mitotic arrest. This modulation of the checkpoint may indirectly impact MKLP-1 by altering its operational context within the mitotic spindle. | ||||||
MLN 8054 | 869363-13-3 | sc-484828 | 5 mg | $398.00 | ||
An Aurora A kinase inhibitor, MLN8054 disrupts mitotic spindle assembly. This disruption potentially affects MKLP-1 indirectly by altering the cellular framework within which MKLP-1 operates during cytokinesis. | ||||||