AZ 3146 (CAS 1124329-14-1)

AZ 3146 is a highly selective inhibitor that targets the mitotic checkpoint kinase Monopolar Spindle 1 (Mps1). By interfering with Mps1, AZ 3146 effectively impedes the proper functioning of the spindle assembly checkpoint (SAC), a regulatory mechanism that ensures accurate chromosome segregation during cell division. This disruption leads to premature anaphase onset, resulting in mitotic errors and, consequently, cell cycle arrest or cell death. Given its unique mechanism of action, AZ 3146 has become useful in cancer research, offering insights into the fundamental processes of mitosis and the potential vulnerabilities of cancer cells that are highly dependent on the SAC for survival. Researchers leverage AZ 3146 to elucidate the role of Mps1 in maintaining genomic stability and to explore new therapeutic strategies targeting the mitotic machinery in various cancer models. Its ability to induce mitotic catastrophe in cancer cells underscores its utility in studying the cellular responses to mitotic errors and the potential for exploiting these errors in the development of anticancer strategies.