MICB Activators
MICB activators encompass a diverse array of compounds that indirectly initiate a cascade of intracellular events culminating in the upregulation of MICB expression. These activators work by modulating specific signaling pathways and transcription factors that govern the transcriptional machinery of the MICB gene. The increase in MICB protein levels enhances its visibility to the immune system, particularly to NKG2D receptor-expressing cells like natural killer (NK) cells and some T-cell populations, thus facilitating the immune surveillance process.
The complexity of the activation mechanisms is mirrored in the variety of pathways targeted by these chemicals. From PKC activation by agents like Prostratin and PMA, which subsequently amplify NF-κB signaling and its nuclear effects on gene expression, to the elevation of intracellular cAMP levels by Forskolin and Dibutyryl cAMP, leading to PKA activation and its downstream genomic effects, each activator operates within a well-characterized signaling context. Additionally, modulation of calcium signaling by Ionomycin and alterations in gene expression patterns through agents like Retinoic acid and HMBA reflect the broad spectrum of cellular processes that can influence MICB expression. Through their distinct but interconnected pathways, these activators collectively contribute to the regulation of MICB, a crucial ligand in the immune system's arsenal against cellular stress and transformation.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator that leads to the activation of AP-1 transcription factor. AP-1 can bind to the MICB promoter region to enhance its transcription. This increase in transcription amplifies MICB mRNA levels, leading to greater protein synthesis and subsequent presentation on the cell surface. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Prostratin activates PKC, which in turn can enhance the transcriptional activity of NF-κB. The active NF-κB translocates to the nucleus and binds to the MICB promoter, increasing the gene's expression and surface expression of the protein. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates PKC and can simulate the T-cell activation pathway, leading to an increase in NF-κB activity. This activation promotes the expression of various genes including MICB, facilitating its upregulation. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a PKC modulator that can upregulate MICB expression by mimicking diacylglycerol. Its binding to PKC leads to the activation of transcription factors, such as NF-κB, which can bind to the MICB promoter and stimulate its expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, thereby activating calcineurin and NFAT signaling pathways. Activated NFAT translocates to the nucleus and can augment transcription of MICB, leading to its increased expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) and activation of PKA. PKA can phosphorylate transcription factors that enhance the transcription of genes, potentially including MICB, resulting in its upregulation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cAMP analog that activates PKA, influencing transcription factors involved in the expression of MICB, thereby potentially promoting its upregulation. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $175.00 $370.00 | 24 | |
Batimastat is a matrix metalloproteinase inhibitor, and while it is commonly associated with inhibition, in certain contexts, it can lead to compensatory cellular responses that upregulate stress-induced ligands like MICB as part of a cell's stress response. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, regulates gene expression through its nuclear receptors. It can upregulate the transcription of various genes, potentially including MICB, by influencing gene expression patterns as part of the immune response. | ||||||
Hexamethylene Biscetamide | 3073-59-4 | sc-204772 sc-204772A | 25 g 50 g | $102.00 $204.00 | ||
HMBA is a hybrid polar compound known to induce differentiation and gene expression. It can activate the transcription of a range of genes, possibly including MICB, by affecting chromatin structure and gene accessibility. | ||||||