mGluR-5 Activators
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Items 11 to 17 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
cis-ACPD | 39026-63-6 | sc-202102 | 5 mg | $60.00 | ||
Cis-ACPD acts as a potent agonist for mGluR5, uniquely engaging the receptor to initiate intracellular signaling pathways. Its structural conformation allows for effective binding to the receptor's orthosteric site, leading to enhanced activation of phospholipase C and subsequent inositol trisphosphate production. This compound's ability to modulate calcium release from intracellular stores plays a crucial role in synaptic transmission and neuronal communication, influencing various neurophysiological processes. | ||||||
(S)-4C3H-PG | 85148-82-9 | sc-203249 sc-203249A | 1 mg 5 mg | $30.00 $123.00 | ||
(S)-4C3H-PG selectively targets mGluR5, exhibiting a unique binding affinity that stabilizes the receptor in an active conformation. This interaction promotes downstream signaling cascades, particularly enhancing the activation of protein kinase pathways. Its distinct stereochemistry facilitates specific molecular interactions, influencing receptor dimerization and altering synaptic plasticity. The compound's kinetic profile suggests rapid receptor engagement, contributing to its dynamic role in cellular signaling networks. | ||||||
trans-(1S,3R)-ACPD | 111900-32-4 | sc-391145 | 5 mg | $197.00 | ||
Trans-(1S,3R)-ACPD is a potent mGluR5 agonist that uniquely modulates receptor activity through its stereospecific interactions. This compound enhances intracellular calcium mobilization, triggering a cascade of signaling events that influence neuronal excitability. Its ability to stabilize receptor conformations allows for prolonged signaling, while its distinct molecular structure promotes selective receptor interactions, impacting synaptic transmission and plasticity. The compound's rapid kinetics enable swift modulation of cellular responses, underscoring its role in neurophysiological processes. | ||||||
VU 0357121 | 433967-28-3 | sc-364645 sc-364645A | 10 mg 50 mg | $145.00 $615.00 | ||
VU 0357121 is a selective mGluR5 antagonist that exhibits unique binding characteristics, disrupting receptor-mediated signaling pathways. Its distinct molecular architecture allows for high affinity interactions with the allosteric site, leading to altered receptor conformations. This modulation results in decreased intracellular calcium levels and influences downstream signaling cascades. The compound's rapid dissociation kinetics facilitate dynamic regulation of synaptic activity, highlighting its role in neuronal communication. | ||||||
DPAP | 890764-36-0 | sc-364741 sc-364741A | 1 mg 5 mg | $64.00 $99.00 | ||
DPAP acts as a selective modulator of mGluR5, showcasing a unique ability to stabilize receptor conformations through specific hydrogen bonding and hydrophobic interactions. Its distinct structural features enable it to engage with the receptor's allosteric site, influencing ligand binding dynamics. This interaction alters the receptor's signaling profile, impacting intracellular pathways and calcium flux. The compound's kinetic properties allow for precise temporal control over receptor activity, underscoring its role in synaptic modulation. | ||||||
Fenobam | 57653-26-6 | sc-202608 sc-202608A | 5 mg 25 mg | $86.00 $306.00 | ||
Fenobam is a negative allosteric modulator of mGluR-5, exerting inhibitory effects on the receptor's response to glutamate, thereby modulating its activation. | ||||||
(±)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid | 67684-64-4 | sc-287072 sc-287072A sc-287072B | 1 mg 5 mg 10 mg | $35.00 $103.00 $187.00 | ||
(+/-)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid exhibits intriguing properties as a modulator of mGluR5, characterized by its capacity to form intricate electrostatic interactions with the receptor. Its unique stereochemistry facilitates selective binding, enhancing receptor activation and influencing downstream signaling cascades. The compound's dynamic conformational flexibility allows it to adapt to various binding states, thereby fine-tuning the receptor's functional responses and impacting synaptic plasticity. | ||||||