Molecular structure of Fenobam, CAS Number: 57653-26-6
Fenobam (CAS 57653-26-6)
Application:
Fenobam is a potent and selective non-competitive mGluR5 antagonist
CAS Number:
57653-26-6
Purity:
≥98%
Molecular Weight:
266.69
Molecular Formula:
C11H11ClN4O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fenobam is a compound that has been explored primarily for its action as a non-competitive mGluR5 (metabotropic glutamate receptor 5) antagonist. In research outside of clinical settings, it serves as useful in neurological studies aimed at understanding glutamatergic signaling and its implications for neuroplasticity and excitotoxicity. The compound′s antagonistic properties have made it a point of focus in investigating the pathophysiology of diseases characterized by overactivation of glutamate receptors. Additionally, Fenobam provides a means to study the potential modulation of synaptic transmission and its effects on neuronal circuits, which is critical for the development of new strategies to study brain function. Its use in research models aids in deciphering the complex roles of mGluR5 receptors in various aspects of cognition and behavior.
Fenobam (CAS 57653-26-6) References
- Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. | Porter, RH., et al. 2005. J Pharmacol Exp Ther. 315: 711-21. PMID: 16040814
- Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues. | Wållberg, A., et al. 2006. Bioorg Med Chem Lett. 16: 1142-5. PMID: 16380255
- The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning. | Jacob, W., et al. 2009. Neuropharmacology. 57: 97-108. PMID: 19426746
- A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys. | Rylander, D., et al. 2010. Neurobiol Dis. 39: 352-61. PMID: 20452425
- Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice. | Montana, MC., et al. 2011. Anesthesiology. 115: 1239-50. PMID: 22037639
- Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency. | Ahn, EH., et al. 2013. BMB Rep. 46: 561-6. PMID: 24152913
- Combined fenobam and amantadine treatment promotes robust antidyskinetic effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson's disease. | Ko, WK., et al. 2014. Mov Disord. 29: 772-9. PMID: 24610195
- The mGluR5 antagonist fenobam induces analgesic conditioned place preference in mice with spared nerve injury. | Lax, NC., et al. 2014. PLoS One. 9: e103524. PMID: 25061818
- Effects of mGluR5 positive and negative allosteric modulators on brain damage evoked by hypoxia-ischemia in neonatal rats. | Makarewicz, D., et al. 2015. Folia Neuropathol. 53: 301-8. PMID: 26785364
- Docking, Molecular Dynamics Simulation and Synthesis of New Fenobam Analogues as mGlu5 Receptor Antagonists. | Javidan, A., et al. 2016. Comb Chem High Throughput Screen. 19: 764-770. PMID: 27585831
- The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans. | Varnäs, K., et al. 2020. Neuropharmacology. 162: 107809. PMID: 31589885
- Determination of tautomeric preference of fenobam in solution by high-resolution NMR spectroscopy. | Sha, X., et al. 2021. Magn Reson Chem. 59: 641-647. PMID: 33368586
- DMSO Delays Alzheimer Disease Causing Aβ-induced Paralysis in C. elegans Through Modulation of Glutamate/Acetylcholine Neurotransmission. | Sadananda, G., et al. 2021. Ann Neurosci. 28: 55-64. PMID: 34733055
- Novel non-benzodiazepine anxiolytics. | Goldberg, ME., et al. 1983. Neuropharmacology. 22: 1499-504. PMID: 6142427
- In vitro and in vivo metabolism of the antianxiolytic agent fenobam in the rat. | Wu, WN., et al. 1995. J Pharm Sci. 84: 185-9. PMID: 7738798
Inhibitor of:
EAAT3, mGluR-1, mGluR-5, mGluR-6, and PAMCI.Activator of:
EG632778, and mGluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fenobam, 5 mg | sc-202608 | 5 mg | $86.00 | |||
Fenobam, 25 mg | sc-202608A | 25 mg | $306.00 |