trans-(1S,3R)-ACPD CAS: 111900-32-4
MF: C7H11NO4
MW: 173.17
A rigid glutamate analog and mGluR activator.

trans-(1S,3R)-ACPD (CAS 111900-32-4)

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Alternate Names: trans-(1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid
Application: trans-(1S,3R)-ACPD is a rigid glutamate analog and mGluR activator
CAS Number: 111900-32-4
Molecular Weight: 173.17
Molecular Formula: C7H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Trans-(1S,3R)-ACPD, or trans-1-amino-1,3-dicarboxycyclopentane, is a rigid analog of the neurotransmitter glutamate and a selective agonist of mGluR (metabotropic glutamate receptors). Trans-(1S,3R)-ACPD excites and modulates neuronal activity comparable to the actions of α-kainic acid, producing depolarization of the neuron and subsequent excitation. Seizure and neuronal injury are reported with exposure to Trans-(1S,3R)-ACPD, mediated by mobilization of intracellular calcium stores. Trans-(1S,3R)-ACPD is also described to stimulate phosphoinositide hydrolysis. Trans-(1S,3R)-ACPD is the active isomer of (±)-trans-ACPD preparations. Trans-(1S,3R)-ACPD is an activator of mGluR-2, mGluR-5, mGluR-6.

Appearance :
Powder
Physical State :
solid
Melting Point :
283.04° C (Predicted)
Density :
1.45 g/cm3 (Predicted)
Optical Activity :
α20/D -22°, c = 0.5 in water
pK Values :
pKa: 2.11 (Predicted), 9.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
104766
SMILES :
C1C[[email protected]](C[[email protected]@H]1C(=O)O)(C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

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