mGluR-5 Antibody (1B3): sc-293442

mGluR-5 Antibody (1B3) is a mouse monoclonal IgG2a kappa light chain antibody that detects mGluR-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-mGluR-5 antibody (1B3) is available as a non-conjugated format. mGluR-5, also known as metabotropic glutamate receptor 5, plays a crucial role in the central nervous system by mediating synaptic transmission and plasticity, which are essential for learning and memory processes. mGluR-5 is primarily located in the postsynaptic membrane of neurons, where mGluR-5 interacts with various signaling pathways, including the phosphatidylinositol-calcium second messenger system, to modulate neuronal excitability and neurotransmitter release. mGluR-5 has been implicated in several neurological disorders, making mGluR-5 a significant target for therapeutic intervention. mGluR-5′s ability to form complexes with other proteins, such as SIAH-1, RyR-1, RyR-2, ITPR1, Shank 1, Shank 3, and GRASP, highlights mGluR-5′s role in synaptic signaling and potential for dysregulation in disease states. The PPXXf motif of mGluR-5 further enhances mGluR-5′s interaction with proteins like HOM1, HOM2, and HOM3, underscoring the complexity of mGluR-5′s functional network.

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mGluR-5 Antibody (1B3) References:

1. A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons.  |  Yang, L., et al. 2004. J Neurosci. 24: 10846-57. PMID: 15574735
2. Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5.  |  Ametamey, SM., et al. 2006. J Nucl Med. 47: 698-705. PMID: 16595505
3. Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.  |  Belozertseva, IV., et al. 2007. Eur Neuropsychopharmacol. 17: 172-9. PMID: 16630709
4. Immunolocalization of metabotropic glutamate receptors 1 and 5 in the synaptic layers of the chicken retina.  |  Sen, M. and Gleason, E. 2006. Vis Neurosci. 23: 221-31. PMID: 16638174
5. Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats.  |  Molina-Hernández, M., et al. 2006. Prog Neuropsychopharmacol Biol Psychiatry. 30: 1129-35. PMID: 16759778
6. The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats.  |  Koros, E., et al. 2007. Neuropsychopharmacology. 32: 562-76. PMID: 16794564
7. Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5.  |  Shueb, SS., et al. 2019. Neuropharmacology. 160: 107690. PMID: 31271770
8. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.  |  Spurrier, J., et al. 2022. Sci Transl Med. 14: eabi8593. PMID: 35648810
9. mGluR5 from Primary Sensory Neurons Promotes Opioid-Induced Hyperalgesia and Tolerance by Interacting with and Potentiating Synaptic NMDA Receptors.  |  Jin, D., et al. 2023. J Neurosci. 43: 5593-5607. PMID: 37451981
10. Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease.  |  Toledano-Zaragoza, A., et al. 2024. Cell Death Dis. 15: 771. PMID: 39443481
11. A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon.  |  Minakami, R., et al. 1993. Biochem Biophys Res Commun. 194: 622-7. PMID: 7688218
12. Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.  |  Minakami, R., et al. 1994. Biochem Biophys Res Commun. 199: 1136-43. PMID: 7908515

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mGluR-5 Antibody (1B3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-mGluR-5 Antibody (1B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mGluR-5 Antibody (1B3) Specifications

Alternate Product Name: mGluR5

Product Clone Name: 1B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 419-518

Epitope Target: mGluR-5

Epitope Species: human

Product Reactivity/Detection: mGluR-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for mGluR-5 Antibody (1B3): N/A