Mdr-1 Inhibitors
SEE ALSO...
Items 1 to 10 of 21 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PSC 833 | 121584-18-7 | sc-361298 sc-361298A sc-361298B sc-361298C sc-361298D | 1 mg 10 mg 50 mg 100 mg 1 g | $213.00 $724.00 $2522.00 $4253.00 $26884.00 | 12 | |
PSC-833 is a non-immunosuppressive cyclosporine derivative that inhibits MDR-1 by blocking drug efflux through P-glycoprotein. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can inhibit MDR-1 by blocking the efflux of drugs through P-glycoprotein, thus increasing intracellular drug levels. | ||||||
MK-571 | 115103-85-0 | sc-201340 sc-201340A | 5 mg 25 mg | $107.00 $413.00 | 8 | |
MK-571 functions as a multidrug resistance (MDR) modulator by inhibiting the activity of the Mdr-1 transporter. It engages in specific binding interactions that alter the conformational dynamics of the transporter, effectively blocking the efflux of various substrates. This modulation can lead to increased intracellular concentrations of co-administered compounds, thereby influencing their pharmacokinetics and bioavailability. Its unique structural features allow for selective inhibition, impacting cellular transport mechanisms. | ||||||
JS-2190 | sc-221784 | 5 mg | $170.00 | |||
JS-2190 acts as a multidrug resistance (MDR) modulator by selectively interacting with the Mdr-1 transporter. Its unique molecular structure facilitates specific binding that disrupts the transporter's normal function, leading to altered substrate efflux dynamics. This interaction enhances the retention of various compounds within cells, significantly affecting their distribution and metabolic pathways. The compound's distinct kinetic profile allows for targeted modulation of cellular transport processes. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A is an immunosuppressive drug that inhibits MDR-1 by binding to P-glycoprotein and preventing its drug efflux activity. | ||||||
Zosuquidar trihydrochloride | 167465-36-3 | sc-364314 sc-364314A | 5 mg 10 mg | $138.00 $330.00 | 2 | |
Zosuquidar trihydrochloride functions as a potent modulator of the Mdr-1 transporter, exhibiting a unique affinity for its binding sites. This compound alters the conformational dynamics of the transporter, impacting substrate recognition and translocation efficiency. Its specific interactions can lead to a pronounced alteration in cellular efflux mechanisms, thereby influencing the intracellular accumulation of various substrates. The compound's behavior is characterized by distinct kinetic properties that facilitate nuanced control over transport activity. | ||||||
Sipholenol A | 78518-73-7 | sc-222313 | 100 µg | $200.00 | ||
Sipholenol A exhibits a unique mechanism of action as a modulator of the Mdr-1 transporter, characterized by its ability to stabilize specific conformations of the protein. This stabilization alters the transporter's affinity for various substrates, impacting the kinetics of efflux processes. Its distinctive hydrophobic regions facilitate interactions with membrane lipids, potentially influencing membrane fluidity and transport efficiency. The compound's intricate molecular architecture plays a crucial role in its transport modulation capabilities. | ||||||
Matairesinol | 580-72-3 | sc-205379 sc-205379A sc-205379B | 1 mg 5 mg 25 mg | $56.00 $170.00 $795.00 | ||
Matairesinol acts as a selective modulator of the Mdr-1 transporter, engaging in specific molecular interactions that enhance its binding affinity. This compound influences the transporter's conformational states, thereby affecting substrate specificity and transport kinetics. Its unique structural features allow for tailored interactions with lipid membranes, potentially altering permeability and efflux rates. The compound's distinct behavior in cellular environments underscores its role in modulating transport dynamics. | ||||||
P-Glycoprotein Inhibitor, C-4 | sc-222109 | 10 mg | $430.00 | |||
P-Glycoprotein Inhibitor, C-4 operates through a distinctive binding affinity that disrupts the normal function of the Mdr-1 transporter. By engaging in specific hydrogen bonding and hydrophobic interactions, it alters the conformational dynamics of the protein, leading to a reduced substrate translocation rate. This compound's unique structural features enhance its ability to interfere with the ATPase activity of the transporter, thereby modulating its efflux capacity and influencing cellular accumulation of various compounds. | ||||||
Reversin 121 | 174630-04-7 | sc-205969 | 5 mg | $300.00 | 2 | |
Reversin 121 exhibits a remarkable ability to modulate the Mdr-1 transporter by engaging in selective molecular interactions that stabilize its inactive conformation. This compound disrupts the ATP hydrolysis cycle, effectively diminishing the energy-dependent efflux mechanism. Its unique structural motifs facilitate specific van der Waals forces and electrostatic interactions, leading to altered substrate affinity and a significant impact on the transport kinetics of various substrates. | ||||||