Date published: 2026-5-4

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Reversin 121 (CAS 174630-04-7)

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Alternate Names:
Boc-Asp(Obzl)-Lys(Z)-OtBu
Application:
Reversin 121 is an inhibitor of P-glycoprotein (MDR1)
CAS Number:
174630-04-7
Purity:
≥98%
Molecular Weight:
641.75
Molecular Formula:
C34H47N3O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Reversin 121 is a small molecule used in biochemical and cellular research due to its ability to modulate multidrug resistance (MDR) in cancer cells. It is characterized as an MDR modulator that can sensitize resistant cells to chemotherapeutic agents by inhibiting the function of ATP-binding cassette (ABC) transporters, which are responsible for the efflux of chemicals from cells. In cellular models, Reversin 121 is employed to study the mechanisms of drug resistance and to explore strategies for overcoming MDR in the context of cancer research. The compound has also been useful for investigating the biochemical profiles of ABC transporters and their role in the transport of various substrates across cellular membranes. Furthermore, Reversin 121 is utilized in the development of assays for the screening of compounds that may affect the activity of drug efflux pumps.


Reversin 121 (CAS 174630-04-7) References

  1. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells.  |  Sharom, FJ., et al. 1999. Biochem Pharmacol. 58: 571-86. PMID: 10413294
  2. Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies.  |  Sharom, FJ., et al. 1999. Biochim Biophys Acta. 1461: 327-45. PMID: 10581365
  3. P-glycoprotein expression in human retinal pigment epithelium.  |  Kennedy, BG. and Mangini, NJ. 2002. Mol Vis. 8: 422-30. PMID: 12432340
  4. Gene amplification and expression in lung cancer cells with acquired paclitaxel resistance.  |  Yabuki, N., et al. 2007. Cancer Genet Cytogenet. 173: 1-9. PMID: 17284363
  5. T lymphocytes impair P-glycoprotein function during neuroinflammation.  |  Kooij, G., et al. 2010. J Autoimmun. 34: 416-25. PMID: 19959334
  6. Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.  |  Arnaud, O., et al. 2010. J Med Chem. 53: 6720-9. PMID: 20731360
  7. ATP-binding cassette transporters modulate both coelenterazine- and D-luciferin-based bioluminescence imaging.  |  Huang, R., et al. 2011. Mol Imaging. 10: 215-26. PMID: 21496450
  8. Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.  |  Verbrugge, SE., et al. 2012. J Pharmacol Exp Ther. 341: 174-82. PMID: 22235146
  9. Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1.  |  Hawley, TS., et al. 2013. Am J Hematol. 88: 265-72. PMID: 23475625
  10. Carfilzomib and oprozomib synergize with histone deacetylase inhibitors in head and neck squamous cell carcinoma models of acquired resistance to proteasome inhibitors.  |  Zang, Y., et al. 2014. Cancer Biol Ther. 15: 1142-52. PMID: 24915039
  11. Synthesis of poly[N-(2-hydroxypropyl)methacrylamide] conjugates of inhibitors of the ABC transporter that overcome multidrug resistance in doxorubicin-resistant P388 cells in vitro.  |  Subr, V., et al. 2014. Biomacromolecules. 15: 3030-43. PMID: 24978588
  12. Overcoming multidrug resistance in Dox-resistant neuroblastoma cell lines via treatment with HPMA copolymer conjugates containing anthracyclines and P-gp inhibitors.  |  Koziolová, E., et al. 2016. J Control Release. 233: 136-46. PMID: 27189135
  13. Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate.  |  Sivak, L., et al. 2017. Biomaterials. 115: 65-80. PMID: 27886555

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Reversin 121, 5 mg

sc-205969
5 mg
$300.00