P-Glycoprotein Inhibitor, C-4 is a cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein, MDR-1) efflux function. Also reverses the MDR (multidrug resistance) phenotype with no effect on P-gp expression. Significantly enhance Paclitaxel- and Vincristine- induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136. Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782.
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