P-Glycoprotein Inhibitor, C-4 MF: C23H18ClNO4
MW: 407.9
A reversible inhibitor of P-glycoprotein(MDR-1) efflux function.

P-Glycoprotein Inhibitor, C-4

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Alternate Names: (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide
Application: P-Glycoprotein Inhibitor, C-4 is a reversible inhibitor of P-glycoprotein(MDR-1) efflux function
Purity: ≥95%
Molecular Weight: 407.9
Molecular Formula: C23H18ClNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

P-Glycoprotein Inhibitor, C-4 is a cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein, MDR-1) efflux function. Also reverses the MDR (multidrug resistance) phenotype with no effect on P-gp expression. Significantly enhance Paclitaxel- and Vincristine- induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.


References

Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136. Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
259.72° C (Predicted)
Boiling Point :
543.92° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
B16 : IC50 = 0.59 ug/mL (mouse); HUVEC50 : IC50 = 0.76 ug/mL (human); SiHa : IC50 = 2.3 ug/mL (human); Vero : IC50 = 3.82 ug/mL (Chlorocebus aethiops)
pK Values :
pKa: 9.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16062976
MDL Number :
MFCD09260351
SMILES :
COC1=C(C=CC(=C1)/C=C/C(=O)C2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)Cl)O

Download SDS (MSDS)

Certificate of Analysis

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