Zosuquidar trihydrochloride (CAS 167465-36-3)

Zosuquidar trihydrochloride is a potent modulator of Mdr-1(P-glycoprotein-mediated multidrug resistance). This compound exhibits an IC50=60 nM. Zosuquidar trihydrochloride competitively inhibits equillibrium binding of drugs to Mdr-1 and shows an ability to reverse drug resistance to multiple oncolytics. Zosuquidar, also known as Zosuquidar trihydrochloride, is a powerful substance used in scientific research to examine the impact of P-glycoprotein (P-gp) inhibition on cellular processes. P-gp is a transmembrane protein responsible for expelling various drugs and molecules from cells. Zosuquidar acts as a substrate for P-gp and functions as a reversible inhibitor of this transporter. By binding to P-gp, Zosuquidar impedes its ability to pump drugs and molecules out of cells. This action results in elevated concentrations of drugs within the cells while reducing their levels outside the cells. As a consequence, Zosuquidar can enhance the effectiveness of drugs while minimizing their toxicity. Furthermore, Zosuquidar has been observed to modulate the activity of P-gp-dependent drug transporters, leading to alterations in the pharmacokinetics of drugs.