Zosuquidar trihydrochloride is a potent modulator of P-glycoprotein-mediated(Mdr-1) multidrug resistance. This compound exhibits an IC50=60 nM. Zosuquidar trihydrochloride competitively inhibits equillibrium binding of drugs to Mdr-1 and shows an ability to reverse drug resistance to multiple oncolytics.
See how others have used Zosuquidar trihydrochloride (CAS 167465-36-3). Click on the entry to view the PubMed entry .
PMID: # 27835832 Jeong, CB. et al. 2017. Comp. Biochem. Physiol. Part D Genomics Proteomics. 21: 17-26.
PMID: # 28073050 Jeong, CB. et al. 2017. Aquat. Toxicol. 183: 144-155.
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