Zosuquidar trihydrochloride CAS: 167465-36-3
MF: C32H31F2N3O2•3HCl
MW: 636.99
A modulator of Pgp.

Zosuquidar trihydrochloride (CAS 167465-36-3)

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Alternate Names: LY335979; RS-33295-198
Application: Zosuquidar trihydrochloride is a modulator of Pgp
CAS Number: 167465-36-3
Purity: ≥98%
Molecular Weight: 636.99
Molecular Formula: C32H31F2N3O23HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Zosuquidar trihydrochloride is a potent modulator of P-glycoprotein-mediated(Mdr-1) multidrug resistance. This compound exhibits an IC50=60 nM. Zosuquidar trihydrochloride competitively inhibits equillibrium binding of drugs to Mdr-1 and shows an ability to reverse drug resistance to multiple oncolytics.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/mL at 25 °C), water (23 mg/mL at 25 °C), ethanol (<1 mg/mL at 25 °C), and methanol.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.69 (Predicted)
Ki Data :
P-glycoprotein: Ki= 60 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
153997
MDL Number :
MFCD00942300
SMILES :
C1CN(CCN1C[[email protected]](COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5[[email protected]]6[[email protected]](C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Zosuquidar trihydrochloride (CAS 167465-36-3)  Product Citations

See how others have used Zosuquidar trihydrochloride (CAS 167465-36-3). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27835832  Jeong, CB. et al. 2017. Comp. Biochem. Physiol. Part D Genomics Proteomics. 21: 17-26.

PMID: # 28073050  Jeong, CB. et al. 2017. Aquat. Toxicol. 183: 144-155.

Citations 1 to 2 of 2 total
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