Sipholenol A efficiently inhibits the function of P-glycoprotein (Pgp, MDR-1). It is a new reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. This has antiproliferative activity, and is cytotoxic. By inhibiting MDR-1, active compounds remain in the cytoplasm longer, allowing them to be more effective within the cell.
S. Carmely & Y. Kashman; J. Org. Chem. 48, 3517 (1983). S. Jain, et al.; J. Nat. Prod. 70, 928 (2007). Z. Shi, et al.; Cancer Sci. 98, 1373 (2007). S. Jain, et al.; Planta Med. 73, 591 (2007).
Soluble in DMSO or 100% ethanol (25mg/ml).
Store at room temperature
230.02° C (Predicted)
~572.3° C at 760 mmHg (Predicted)
~1.0 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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