JS-2190
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JS-2190 stands out as a potent inhibitor of both Mdr-1 (P-glycoprotein, Pgp) and MRP1, pivotal components in the cellular efflux mechanism that actively transport a wide variety of substances across cellular membranes. The efficacy of JS-2190 has been underscored through the calcein assay protocol, which demonstrates its efficient uptake by living cells. This characteristic underscores its utility in research, particularly in studying the modulation of cellular transport mechanisms that play a role in the efflux of xenobiotics and endogenous substances. By inhibiting these efflux pumps, JS-2190 provides useful for investigating the dynamics of cellular resistance mechanisms and substance distribution within cells, offering insights into the fundamental processes that govern cellular homeostasis and xenobiotic disposition.
JS-2190 References
- Effects of cadmium exposure on expression and activity of P-glycoprotein in eastern oysters, Crassostrea virginica Gmelin. | Ivanina, AV. and Sokolova, IM. 2008. Aquat Toxicol. 88: 19-28. PMID: 18453012
- American Academy of Optometry Geographical Directory of Members. | Schoen, JN. 1976. Am J Optom Physiol Opt. 53: 586-641. PMID: 790969
- Determination of Energy Requirements for P-glycoprotein Function in Eastern Oysters, Crassostrea virginica | Kristen Nicole Reynolds, Inna Sokolova. 2008. 22: 57.23-757.23.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JS-2190, 5 mg | sc-221784 | 5 mg | $170.00 |