MCT2 Activators
MCT2 Activators are a class of chemical compounds that target and modulate the activity of the Monocarboxylate Transporter 2 (MCT2). MCT2 is a specialized transmembrane protein primarily found in various tissues throughout the human body, including the brain, heart, and skeletal muscles. Its main function is the transport of monocarboxylates, such as lactate, pyruvate, and ketone bodies, across cell membranes. These monocarboxylates play crucial roles in energy metabolism, with pyruvate serving as a pivotal metabolite at the crossroads of glycolysis and oxidative phosphorylation. MCT2, therefore, acts as a gatekeeper in the cellular uptake and release of these metabolites, and its activity can profoundly influence cellular energy production and metabolic homeostasis.
MCT2 Activators are chemical entities designed to enhance or regulate the transport activity of MCT2. By modulating MCT2 function, these compounds have the potential to impact various physiological processes dependent on the transport of monocarboxylates. This may include providing additional energy substrates to cells during periods of high demand, improving the utilization of lactate as an energy source, or regulating the balance between glycolysis and oxidative phosphorylation. While the specific mechanisms by which MCT2 Activators interact with and alter MCT2 function may vary, their overarching goal is to fine-tune the transport of monocarboxylates, thereby influencing cellular metabolism and energy production. Further research is required to elucidate the full spectrum of their effects and potential applications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol found in grapes and red wine, has been studied for its potential to upregulate MCT2 expression, possibly through activating certain signaling pathways that promote cellular adaptation to metabolic changes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Found in turmeric, curcumin has shown the ability to influence the expression of MCT2. It may modulate metabolic activity and cellular transport processes, contributing to altered MCT2 levels. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Widely used for managing blood sugar levels, metformin has been observed to influence MCT2 expression, potentially through its effects on cellular energy metabolism. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A, retinoic acid is known for its role in cell growth and differentiation. It may also play a role in modulating MCT2 expression in specific tissue types. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A synthetic glucocorticoid, dexamethasone can affect the expression of various proteins, including MCT2, possibly through its anti-inflammatory effects and influence on cellular metabolism. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Another glucocorticoid, hydrocortisone may alter MCT2 expression as part of its wide-ranging effects on metabolism and inflammation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Derived from the Coleus forskohlii plant, forskolin is known to activate adenylate cyclase, potentially influencing MCT2 expression through cAMP-mediated signaling pathways. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $51.00 $138.00 | ||
Found in green tea and dark chocolate, epicatechin is a flavonoid that may modulate MCT2 expression, possibly through its antioxidant properties and effects on metabolic signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Present in cruciferous vegetables, sulforaphane has been studied for its potential to influence MCT2 expression, possibly through its effects on detoxification enzymes and cellular antioxidant status. | ||||||
3-Bromopyruvic acid | 1113-59-3 | sc-260854 sc-260854A sc-260854B sc-260854D sc-260854C sc-260854E | 1 g 5 g 10 g 50 g 100 g 500 g | $47.00 $84.00 $119.00 $386.00 $818.00 $2452.00 | 7 | |
As an inhibitor of glycolysis, 3-bromopyruvate may influence MCT2 expression by altering cellular energy balance and metabolic state. | ||||||