MCT2 Antibody (D-5): sc-166925
- MCT2 Antibody (D-5) is a mouse monoclonal IgG2b κ MCT2 antibody, cited in 22 publications, provided at 200 µg/ml
- raised against amino acids 391-480 mapping at the C-terminus of MCT2 of mouse origin
- MCT2 Antibody (D-5) is recommended for detection of MCT2 of mouse origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MCT2 Antibody (D-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MCT2 Antibody (D-5) for WB and IHC(P) applications. These reagents are now offered in bundles with MCT2 Antibody (D-5) (see ordering information below).
QUICK LINKS
MCT2 Antibody (D-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects MCT2 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MCT2 (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MCT2, also known as SLC16A7, is a member of the monocarboxylate transporter family, which plays a crucial role in cellular metabolism by facilitating the transport of monocarboxylates such as lactate and pyruvate across cell membranes. This transport is vital for maintaining cellular energy homeostasis, particularly during periods of high glycolytic activity, as MCT2 allows for the removal of lactic acid, which can accumulate and lead to decreased intracellular pH, ultimately inhibiting glycolysis. MCT2 is predominantly expressed in the liver and testis, where MCT2 contributes to the regulation of metabolic processes and the transport of metabolites necessary for energy production and cellular function. Understanding MCT2′s role in these tissues is essential for elucidating MCT2′s involvement in metabolic disorders and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MCT2 Antibody (D-5) References:
- Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. | Juel, C. and Halestrap, AP. 1999. J Physiol. 517 (Pt 3): 633-42. PMID: 10358105
- The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. | Halestrap, AP. and Price, NT. 1999. Biochem J. 343 Pt 2: 281-99. PMID: 10510291
- Lactate transporters (MCT proteins) in heart and skeletal muscles. | Bonen, A. 2000. Med Sci Sports Exerc. 32: 778-89. PMID: 10776897
- Abundance and subcellular distribution of MCT1 and MCT4 in heart and fast-twitch skeletal muscles. | Bonen, A., et al. 2000. Am J Physiol Endocrinol Metab. 278: E1067-77. PMID: 10827010
- Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer. | Pértega-Gomes, N., et al. 2013. Prostate. 73: 763-9. PMID: 23192371
- Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance. | Hoshino, D., et al. 2016. Neurosci Lett. 633: 1-6. PMID: 27619538
- Cooperative transport mechanism of human monocarboxylate transporter 2. | Zhang, B., et al. 2020. Nat Commun. 11: 2429. PMID: 32415067
- Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis. | Khalyfa, A., et al. 2021. Int J Mol Sci. 22: PMID: 34638954
- Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. | Gerhart, DZ., et al. 1997. Am J Physiol. 273: E207-13. PMID: 9252498
- Lactate transport in heart in relation to myocardial ischemia. | Halestrap, AP., et al. 1997. Am J Cardiol. 80: 17A-25A. PMID: 9293952
- Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. | Price, NT., et al. 1998. Biochem J. 329 (Pt 2): 321-8. PMID: 9425115
- Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. | Lin, RY., et al. 1998. J Biol Chem. 273: 28959-65. PMID: 9786900
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCT2 Antibody (D-5) | sc-166925 | 200 µg/ml | $316.00 | |||
MCT2 Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-521801 | 200 µg Ab, 40 µg BP | $354.00 | |||
MCT2 Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-548969 | 200 µg Ab; 10 µg BP | $354.00 | |||
MCT2 Antibody (D-5) AC | sc-166925 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MCT2 Antibody (D-5) HRP | sc-166925 HRP | 200 µg/ml | $316.00 | |||
MCT2 Antibody (D-5) FITC | sc-166925 FITC | 200 µg/ml | $330.00 | |||
MCT2 Antibody (D-5) PE | sc-166925 PE | 200 µg/ml | $343.00 | |||
MCT2 Antibody (D-5) Alexa Fluor® 488 | sc-166925 AF488 | 200 µg/ml | $357.00 | |||
MCT2 Antibody (D-5) Alexa Fluor® 546 | sc-166925 AF546 | 200 µg/ml | $357.00 | |||
MCT2 Antibody (D-5) Alexa Fluor® 594 | sc-166925 AF594 | 200 µg/ml | $357.00 | |||
MCT2 Antibody (D-5) Alexa Fluor® 647 | sc-166925 AF647 | 200 µg/ml | $357.00 | |||
MCT2 Antibody (D-5) Alexa Fluor® 680 | sc-166925 AF680 | 200 µg/ml | $357.00 | |||
MCT2 Antibody (D-5) Alexa Fluor® 790 | sc-166925 AF790 | 200 µg/ml | $357.00 |