3-Bromopyruvic acid (CAS 1113-59-3)

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Alternate Names: 3-Bromopyruvic acid is also known as 3-Bromo-2-oxopropionic acid.

Application: 3-Bromopyruvic acid is a cross-linker between nucleic acids and proteins, and is also an affinity label for cysteine residues.

CAS Number: 1113-59-3

Purity: ≥97%

Molecular Weight: 166.96

Molecular Formula: C₃H₃BrO₃

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

* Refer to Certificate of Analysis for lot specific data (including water content).

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3-Bromopyruvic acid is a brominated derivative of pyruvic acid (sc-208191), which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 (sc-2206) breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts.

References

1. ZYGMUNT, W.A. and MARTIN, T.A. 1964. J Pharm Sci. 53 : 1420-1421. PMID: 14253613
2. Liu, X.H. et al. 2009. Chin. Med. J. 122(14): 1681-1685. PMID: 19719971

Appearance :

Crystalline

Physical State :

Solid

Solubility :

Soluble in water (100 mg/ml), DMSO, ethyl acetate, and water.

Storage :

Store at 4° C

Melting Point :

77-82° C

Boiling Point :

~223.4° C at 760 mmHg (Predicted)

Density :

~2.0 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.52 (Predicted)

pK Values :

pK_a: 1.84 (Predicted)

WGK Germany :

RTECS :

UZ0840000

PubChem CID :

70684

MDL Number :

MFCD00002587

EC Number :

214-206-5

Beilstein Registry :

1746786

SMILES :

C(C(=O)C(=O)O)Br

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SAMPLE Certificate of Analysis (COA)

3-Bromopyruvic acid | CAS 1113-59-3 SAMPLE Certificate of Analysis

Certificate of Analysis

SAMPLE Certificate of Analysis (COA)

Catalog Number:sc-260854

Lot Number:SAMPLE

Product Name:3-Bromopyruvic acid hydrate

Molecular Formula:C₃H₃BrO₃•H₂O

Molecular Weight:184.97

Test	Specification	Results
Appearance		Light beige powder
Purity (Acid Titration)		98.3%