3-Bromopyruvic acid is a brominated derivative of pyruvic acid (sc-208191), which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 (sc-2206) breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts.
1. Zygunt, W.A. and Martin, T.A. 1964. J Pharm Sci. 53: 1420-1421. PMID: 14253613 2. Liu, X.H., et al. 2009. Chin. Med. J. 122: 1681-1685. PMID: 19719971
Soluble in water (100 mg/ml), DMSO, ethyl acetate, and water.
Store at 4° C
~223.4° C at 760 mmHg (Predicted)
~2.0 g/cm3 (Predicted)
n20D 1.52 (Predicted)
pKa: 1.84 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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