3-Bromopyruvic acid CAS: 1113-59-3
MF: C3H3BrO3
MW: 166.96

3-Bromopyruvic acid (CAS 1113-59-3)

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Alternate Names: 3-Bromopyruvic acid is also known as 3-Bromo-2-oxopropionic acid.
Application: 3-Bromopyruvic acid is a cross-linker between nucleic acids and proteins, and is also an affinity label for cysteine residues.
CAS Number: 1113-59-3
Purity: ≥97%
Molecular Weight: 166.96
Molecular Formula: C3H3BrO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-Bromopyruvic acid is a brominated derivative of pyruvic acid (sc-208191), which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 (sc-2206) breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts.


References

1. ZYGMUNT, W.A. and MARTIN, T.A. 1964. J Pharm Sci. 53 : 1420-1421. PMID: 14253613
2. Liu, X.H. et al. 2009. Chin. Med. J. 122(14): 1681-1685. PMID: 19719971

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), DMSO, ethyl acetate, and water.
Storage :
Store at 4° C
Melting Point :
77-82° C
Boiling Point :
~223.4° C at 760 mmHg (Predicted)
Density :
~2.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
pK Values :
pKa: 1.84 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UZ0840000
PubChem CID :
MDL Number :
MFCD00002587
EC Number :
214-206-5
Beilstein Registry :
1746786
SMILES :
C(C(=O)C(=O)O)Br

Download SDS (MSDS)

Certificate of Analysis

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3-Bromopyruvic acid (CAS 1113-59-3)  Product Citations

See how others have used 3-Bromopyruvic acid (CAS 1113-59-3). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28965765  Cliff, TS. et al. 2017. Cell Stem Cell. 21: 502-516.e9.

PMID: # 26795347  Bacci, M. et al. 2016. Cancer Res. 76: 1615-26.

PMID: # 27723751  Levy, G.|Habib, N.|Guzzardi, MA.|Kitsberg, D.|Bomze, D.|Ezra, E.|Uygun, BE.|Uygun, K.|Trippler, M.|Schlaak, JF.|Shibolet, O.|Sklan, EH.|Cohen, M.|Timm, J.|Friedman, N.|Nahmias, Y.| et al. 2016. Nat. Chem. Biol. 12: 1037-1045.

PMID: # 32615946  BMC Cancer. 617.

PMID: # 32125743  Genes Cells.

PMID: # 31669882  Pharmacol Rep. 1184-1189.

Citations 1 to 6 of 6 total

Is 3-bromopyruvate soluble in saline solution?

Asked by: Abha
Thank you for your question. We found that this is soluble in isotonic saline, but were not able to find a recommended concentration.
Answered by: Technical Support
Date published: 2019-09-11

I want 3-bromopyruvic acid for human clinical trials soon, therefore I need cGMP certification for this product. If I want to order 40kg of this in cGMP level, what's the quotations?

Asked by: bkim019
We cannot provide chemicals regulated as ISO certified and GMP compliant. Our chemicals are for in vitro research use only. Not intended for diagnostic of therapeutic use.
Answered by: Technical Support
Date published: 2021-09-08
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