MCPyV large T-antigen Inhibitors
MCPyV (Merkel cell polyomavirus) large T-antigen inhibitors belong to a specialized class of chemical compounds that are designed to target a specific viral protein known as the large T-antigen. This viral protein plays a crucial role in the life cycle of MCPyV, a polyomavirus that has been linked to Merkel cell carcinoma, a rare but aggressive skin cancer. The large T-antigen is a multifunctional protein essential for viral replication and transformation of host cells. In the context of MCPyV, it is implicated in promoting cellular proliferation and inhibiting apoptosis, which can contribute to the development of Merkel cell carcinoma.
The development of MCPyV large T-antigen inhibitors is rooted in the understanding that blocking this viral protein's activity may disrupt the virus's ability to manipulate host cells and disrupt the progression of infection. These inhibitors are typically small molecules or peptides designed to specifically target and interfere with the large T-antigen's functions. The mechanisms of action can vary, but they often involve disrupting protein-protein interactions, interfering with DNA binding, or inhibiting enzymatic activities associated with the large T-antigen.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts, causing DNA damage that can lead to cell cycle arrest and inhibit viral replication and protein expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
By inhibiting thymidylate synthase, 5-Fluorouracil results in DNA damage and hampers the synthesis of viral proteins. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and disrupts topoisomerase-II activity, potentially reducing MCPyV large T-antigen expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide stabilizes the DNA-topoisomerase II complex, leading to DNA breaks and potentially downregulating viral protein synthesis. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine is incorporated into DNA, causing chain termination and potentially inhibiting viral replication and protein expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may modulate cellular signaling pathways, potentially leading to the suppression of viral oncoproteins. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to modulate various signaling pathways and might play a role in downregulating viral oncoproteins. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
As a flavonoid with antioxidant properties, quercetin might interfere with the cellular environment required for viral replication. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane induces phase II detoxification enzymes and may alter cellular conditions, potentially reducing viral protein expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has been shown to modulate signaling pathways and might inhibit viral oncoproteins. | ||||||