MATH-2 Activators
MATH-2 Activators are a diverse group of chemical compounds that directly enhance the functional activity of MATH-2 through specific signaling pathways or biological processes. These compounds act on various molecular targets and pathways, ultimately leading to the activation of MATH-2 and its involvement in specific cellular processes. One common mechanism of action for MATH-2 Activators is the activation of transcription factors or nuclear receptors. For example, compounds like Retinoic Acid and Retinol activate retinoic acid receptors (RARs), promoting the transcription of MATH-2 and increasing its expression and functional activity. Similarly, Lithium activates the Wnt/β-catenin signaling pathway, leading to the stabilization and nuclear translocation of β-catenin, which interacts with TCF/LEF transcription factors to increase MATH-2 expression and functional activity.
Other MATH-2 Activators, such as Forskolin and Caffeine, act through the cAMP-PKA signaling pathway. These compounds increase intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA phosphorylates and activates MATH-2, enhancing its functional activity in various cellular processes regulated by cAMP-PKA signaling. Furthermore, compounds like Epinephrine and PMA activate protein kinases, such as PKC and CaMK, respectively. Activation of these kinases leads to the phosphorylation and activation of MATH-2, enhancing its functional activity in specific signaling pathways.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is a metabolite of Vitamin A and acts as a ligand for nuclear retinoic acid receptors (RARs). It binds to RARs and activates transcription of target genes, including MATH-2. This leads to increased expression of MATH-2, promoting its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene compound that activates adenylate cyclase, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP). Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates and activates MATH-2, enhancing its functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, also known as adrenaline, acts as a ligand for adrenergic receptors. Binding of epinephrine to these receptors activates the cAMP-PKA pathway, leading to the phosphorylation and activation of MATH-2. This activation enhances the functional activity of MATH-2 in various cellular processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural polyphenol found in grapes and other plants. It activates the Sirtuin 1 (SIRT1) pathway, which deacetylates and activates MATH-2. The activation of MATH-2 by SIRT1 enhances its functional activity, contributing to cellular processes regulated by MATH-2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is a mood stabilizer that activates the Wnt/β-catenin signaling pathway. Activation of this pathway leads to the stabilization and nuclear translocation of β-catenin, which interacts with TCF/LEF transcription factors. The β-catenin-TCF/LEF complex then binds to the promoter region of MATH-2, increasing its expression and functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric. It activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which regulates the antioxidant response. Activation of Nrf2 leads to increased expression of MATH-2, enhancing its functional activity in antioxidant defense mechanisms. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium levels activate calcium/calmodulin-dependent protein kinase (CaMK), which phosphorylates and activates MATH-2. This phosphorylation enhances the functional activity of MATH-2 in calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC). Activation of PKC leads to the phosphorylation and activation of MATH-2, enhancing its functional activity. PKC-mediated activation of MATH-2 is involved in various cellular processes regulated by PKC signaling pathways. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $377.00 $2602.00 | ||
Vitamin A, also known as Retinol, is a precursor of retinoic acid. It is converted to retinoic acid through enzymatic reactions. Increased levels of retinol can lead to elevated retinoic acid levels, which activate retinoic acid receptors (RARs). Activation of RARs promotes the transcription of MATH-2, increasing its expression and functional activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a stimulant that inhibits phosphodiesterase (PDE), leading to increased cAMP levels. Elevated cAMP levels activate PKA, which phosphorylates and activates MATH-2. This activation enhances the functional activity of MATH-2 in various cellular processes regulated by cAMP-PKA signaling pathways. | ||||||