MATH-2 Antibody (3G7): sc-517009
- MATH-2 Antibody (3G7) is a mouse monoclonal IgG2a κ MATH-2 antibody provided at 100 µg/ml
- raised against amino acids 246-337 representing partial length MATH-2 of human origin
- recommended for detection of MATH-2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MATH-2 Antibody (3G7). This work is in progress.
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MATH-2 Antibody (3G7) is a mouse monoclonal IgG2a kappa light chain antibody that detects MATH-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). MATH-2 Antibody (3G7) is available as the non-conjugated anti-MATH-2 antibody (3G7). MATH-2, a helix-loop-helix transcription factor, plays a crucial role in the development and function of the nervous system. Structurally, MATH-2 is homologous to the Drosophila atonal gene product, featuring a basic helix-loop-helix domain essential for gene regulation. MATH-2 is primarily expressed in the developing central nervous system, with significant expression observed in the cortical plate and mantle layer during embryonic development. In adult mice, MATH-2 is predominantly found in the cerebrum, where MATH-2 influences the maintenance of neuronal identity and function. Precise regulation of MATH-2 is vital, as MATH-2 influences the differentiation of neural progenitor cells and the establishment of neuronal circuits, making MATH-2 a key player in neurogenesis and the overall health of the nervous system. Research using anti-MATH-2 antibody (3G7) can provide valuable insights into the molecular mechanisms underlying neural development and potential neurodegenerative conditions.
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MATH-2 Antibody (3G7) References:
- Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. | Schwab, MH., et al. 2000. J Neurosci. 20: 3714-24. PMID: 10804213
- Xath2, a bHLH gene expressed during a late transition stage of neurogenesis in the forebrain of Xenopus embryos. | Taelman, V., et al. 2001. Mech Dev. 101: 199-202. PMID: 11231075
- A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. | Akazawa, C., et al. 1995. J Biol Chem. 270: 8730-8. PMID: 7721778
- MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system. | Shimizu, C., et al. 1995. Eur J Biochem. 229: 239-48. PMID: 7744035
- Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. | Ishibashi, M., et al. 1993. Eur J Biochem. 215: 645-52. PMID: 8354270
- Regulation of mammalian neural development by helix-loop-helix transcription factors. | Kageyama, R., et al. 1995. Crit Rev Neurobiol. 9: 177-88. PMID: 8581982
- Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal. | Isaka, F., et al. 1996. Genomics. 37: 400-2. PMID: 8938455
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MATH-2 Antibody (3G7) | sc-517009 | 100 µg/ml | $322.00 |