MAPKAPK-2 Inhibitors

Rottlerin, CAS 82-08-6, is a natural polyphenol isolated from Mallotus philippinensis. It functions as an inhibitor of MAPKAPK-2, a serine/threonine kinase involved in stress and inflammation signaling pathways. Rottlerin's mechanism of action involves binding to the active site of MAPKAPK-2, leading to the suppression of its kinase activity. Its inhibitory effects on MAPKAPK-2 make it a valuable tool in research aimed at understanding the cellular processes regulated by this kinase.

CID 755673, CAS 521937-07-5, is a small-molecule compound that acts as an inhibitor of MAPKAPK-2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2). It exerts its inhibitory effects by targeting the active site of MAPKAPK-2, preventing its kinase activity. As a specific inhibitor of MAPKAPK-2, CID 755673 is used in research settings to investigate the cellular functions and signaling pathways regulated by this kinase.

SB 203580 is a widely used and well-characterized inhibitor of MAPKAPKIt competitively binds to the ATP-binding pocket of MAPKAPK2, preventing its kinase activity.

MK-2 Inhibitor III, CAS 1186648-22-5, is a specific small-molecule compound designed to inhibit MAPKAPK-2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2). By binding to the active site of MAPKAPK-2, this inhibitor hinders the kinase activity of the enzyme. MK-2 Inhibitor III is widely utilized in research to investigate the cellular processes and signaling pathways regulated by MAPKAPK-2, aiding in the understanding of its biological functions.

Cdc7/Cdk9 Inhibitor, CAS 845714-00-3, is a chemical compound known for its inhibitory effects on Cdc7 and Cdk9 kinases. It does not directly target MAPKAPK-2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2). Instead, this inhibitor affects other kinases involved in cell cycle regulation and transcriptional processes. Its role in cell cycle control makes it valuable in research to explore the functions of Cdc7 and Cdk9, which are crucial for cell division and gene expression.

CMPD1, CAS 41179-33-3, is a small-molecule compound known for its inhibitory action on MAPKAPK-2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2). By specifically targeting the active site of MAPKAPK-2, CMPD1 effectively hinders the kinase activity of the enzyme. This inhibition makes CMPD1 a valuable tool in research aimed at understanding the cellular functions and signaling pathways regulated by MAPKAPK-2, providing valuable insights into its biological role.

"MAPKAP Kinase-2 inhibitor" is a generic term used to refer to compounds that specifically target and inhibit MAPKAPK-2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2). These inhibitors function by binding to the active site of MAPKAPK-2, preventing its kinase activity. As a research tool, MAPKAP Kinase-2 inhibitors are valuable in investigating the cellular processes and signaling pathways regulated by this kinase, aiding in the understanding of its biological functions and potential roles in various cellular contexts.

PHA 767491 hydrochloride, CAS 942425-68-5, is a potent and specific inhibitor of MAPKAPK-2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2). By targeting the active site of MAPKAPK-2, this compound effectively suppresses its kinase activity. PHA 767491 hydrochloride is widely used in research to investigate the cellular functions and signaling pathways regulated by MAPKAPK-2, providing valuable insights into its biological role in various cellular processes.

PF-3644022 is an active and selective MAPKAPK2 inhibitor with anti-inflammatory properties.

CC-401 is a dual inhibitor of MAPKAPK2 and another kinase called P38α MAPK. It has been evaluated for its anti-inflammatory effects.