MAPKAPK-2 Antibody (A-11): sc-393609

MAPKAPK-2 Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAPKAPK-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MAPKAPK-2 antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MAPKAPK-2 plays a crucial role in cellular signaling pathways, particularly in response to stress and inflammatory stimuli, by acting as a downstream effector of p38 MAP kinase and extracellular signal-regulated kinase (ERK) pathways. MAPKAPK-2 is primarily located in the cytoplasm and translocates to the nucleus upon activation, where MAPKAPK-2 regulates gene expression and cell survival. MAPKAPK-2′s ability to modulate these pathways is vital for processes such as cell proliferation, differentiation, and apoptosis, making MAPKAPK-2 an important target for research in cancer and other diseases. MAPKAPK-2 undergoes phosphorylation, a key post-translational modification that enhances activity and stability, further underscoring MAPKAPK-2′s significance in cellular responses to external stimuli.

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MAPKAPK-2 Antibody (A-11) References:

1. MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.  |  Stokoe, D., et al. 1992. EMBO J. 11: 3985-94. PMID: 1327754
2. Co-induction of alphaB-crystallin and MAPKAPK-2 in astrocytes in the penumbra after transient focal cerebral ischemia.  |  Piao, CS., et al. 2005. Exp Brain Res. 163: 421-9. PMID: 15856211
3. MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.  |  Gorog, DA., et al. 2009. Cell Stress Chaperones. 14: 477-89. PMID: 19214782
4. Olive leaf extracts protect cardiomyocytes against 4-hydroxynonenal-induced toxicity in vitro: comparison with oleuropein, hydroxytyrosol, and quercetin.  |  Bali, EB., et al. 2014. Planta Med. 80: 984-92. PMID: 25098929
5. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.  |  Sturgill, TW., et al. 1988. Nature. 334: 715-8. PMID: 2842685
6. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.  |  Zhao, Y., et al. 1995. Mol Cell Biol. 15: 4353-63. PMID: 7623830
7. The mitogen-activated protein kinase signal transduction pathway.  |  Davis, RJ. 1993. J Biol Chem. 268: 14553-6. PMID: 8325833
8. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.  |  Sithanandam, G., et al. 1996. Mol Cell Biol. 16: 868-76. PMID: 8622688
9. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.  |  McLaughlin, MM., et al. 1996. J Biol Chem. 271: 8488-92. PMID: 8626550
10. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.  |  Waskiewicz, AJ., et al. 1997. EMBO J. 16: 1909-20. PMID: 9155017
11. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.  |  Fukunaga, R. and Hunter, T. 1997. EMBO J. 16: 1921-33. PMID: 9155018
12. Identification of mitogen-activated protein kinase-activated protein kinase-2 as a vimentin kinase activated by okadaic acid in 9L rat brain tumor cells.  |  Cheng, TJ. and Lai, YK. 1998. J Cell Biochem. 71: 169-81. PMID: 9779816

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAPKAPK-2 Antibody (A-11) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-MAPKAPK-2 Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAPKAPK-2 Antibody (A-11) Specifications

Alternate Product Name: MAPK Activated Protein Kinase 2

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 372-399

Epitope Target: MAPKAPK-2

Epitope Species: human

Product Reactivity/Detection: MAPKAPK-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for MAPKAPK-2 Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin