Molecular structure of PHA 767491 hydrochloride, CAS Number: 942425-68-5
PHA 767491 hydrochloride (CAS 942425-68-5)
See product citations (3)
Application:
PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor
CAS Number:
942425-68-5
Purity:
≥98%
Molecular Weight:
249.7
Molecular Formula:
C12H11N3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Induces apoptosis in a p53-independent manner in vivo and Inhibits cell proliferation in a variety of human cell lines (IC50 ~ 0.86 - 5.87 μM). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC50 = 171 nM).
Inhibitor of:
Cdc2, Cdc6, Cdc7, Cdk, Cdk1, Cdk2, Cdk7, Cdk9, CDSN, cyclin E, MAPKAPK-2, and PCTAIRE-3.Activator of:
Cdk8, and E2F-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHA 767491 hydrochloride, 10 mg | sc-204187 | 10 mg | $194.00 | |||
| US: Only available in the US | ||||||
PHA 767491 hydrochloride, 50 mg | sc-204187A | 50 mg | $786.00 | |||
| US: Only available in the US | ||||||