Date published: 2025-10-15

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MAPK15 Activators

MAPK15 Activators belong to a distinct chemical class that specifically targets the mitogen-activated protein kinase 15 (MAPK15) pathway within cellular signaling networks. This class of compounds demonstrates a unique ability to stimulate and enhance the activation of MAPK15, a lesser-known member of the mitogen-activated protein kinase family. MAPK15, also referred to as extracellular signal-regulated kinase 8 (ERK8), is a serine/threonine kinase involved in regulating various cellular processes, including cell proliferation, differentiation, migration, and apoptosis. MAPK15 Activators are characterized by their capacity to bind to specific sites within the MAPK15 enzyme, triggering a series of phosphorylation events that culminate in the activation of downstream signaling cascades. Through this mechanism, these compounds play a pivotal role in modulating cellular responses to various extracellular stimuli, ultimately impacting cellular behaviors and physiological outcomes. The unique properties of MAPK15 Activators make them valuable tools for researchers aiming to dissect the intricate pathways regulated by MAPK15 and to uncover its diverse roles in cellular physiology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

KU-0058948

763111-49-5sc-489065
10 mg
$549.00
(0)

KU-0058948 is a compound known for its role as an activator of MAPK15, a protein involved in cellular signaling pathways. It influences specific biological processes related to cellular responses.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$30.00
$60.00
$93.00
27
(1)

Generates reactive oxygen species, potentially activating MAPK15 indirectly through redox signaling, driving various cellular events and responses.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

Directly or indirectly activates MAPK15 through the activation of Protein Kinase C (PKC), influencing various cellular processes.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$97.00
$254.00
36
(2)

Indirectly kick-starts MAPK15 activation through the activation of the JNK pathway, potentially modulating MAPK15-related signaling and cellular responses.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Indirectly initiates MAPK15 activation by altering intracellular calcium levels, potentially activating signaling pathways associated with MAPK15 activation.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

Indirectly promotes MAPK15 activation by inhibiting phosphatases, increasing phosphorylation events within the MAPK pathways.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

Indirectly fires up MAPK15 by altering intracellular calcium levels, potentially initiating MAPK15 signaling and activation.

Sodium Orthovanadate

13721-39-6sc-3540
sc-3540B
sc-3540A
5 g
10 g
50 g
$45.00
$56.00
$183.00
142
(4)

Directly acts as an activator of protein phosphatases, initiating MAPK15 activation through their role in cellular signaling.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Indirectly jumpstarts MAPK15 activation by influencing gene expression, potentially firing up cellular processes related to MAPK15 signaling.