MAPK15 Antibody (168CT10.6.6): sc-517342

MAPK15 Antibody (168CT10.6.6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAPK15 protein of human origin by western blotting (WB) and immunofluorescence (IF). Anti-MAPK15 antibody (168CT10.6.6) is available as a non-conjugated format. MAPK15, also known as mitogen-activated protein kinase 15 or ERK8, is a 544 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family, specifically within the MAP kinase subfamily. MAPK15 plays a crucial role in various biological processes, including cell adhesion, differentiation, and apoptosis, making MAPK15 essential for maintaining cellular homeostasis and responding to extracellular signals. MAPK15 functions as a catalytic kinase, utilizing ATP to generate ADP and a phosphoprotein, and becomes activated through phosphorylation at a TXY motif, which includes a threonine and a tyrosine residue. MAPK15 is widely expressed throughout the body, with highest levels found in the lung and kidney, indicating MAPK15′s importance in organ-specific functions and potential implications in various diseases.

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MAPK15 Antibody (168CT10.6.6) References:

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2. gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.  |  Kinet, S., et al. 2002. Blood. 100: 2546-53. PMID: 12239168
3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.  |  Suzuki, Y., et al. 2004. Genome Res. 14: 1711-8. PMID: 15342556
4. Counting on mitogen-activated protein kinases--ERKs 3, 4, 5, 6, 7 and 8.  |  Bogoyevitch, MA. and Court, NW. 2004. Cell Signal. 16: 1345-54. PMID: 15381250
5. A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension.  |  Ellis, J., et al. 2004. Mol Microbiol. 53: 1487-99. PMID: 15387824
6. Characterization of the reversible phosphorylation and activation of ERK8.  |  Klevernic, IV., et al. 2006. Biochem J. 394: 365-73. PMID: 16336213
7. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.  |  Iavarone, C., et al. 2006. J Biol Chem. 281: 10567-76. PMID: 16484222
8. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.  |  Saelzler, MP., et al. 2006. J Biol Chem. 281: 16821-32. PMID: 16624805
9. Toxoplasma gondii expresses two mitogen-activated protein kinase genes that represent distinct protozoan subfamilies.  |  Lacey, MR., et al. 2007. J Mol Evol. 64: 4-14. PMID: 17160647