MALAT-1 Inhibitors
MALAT-1 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of MALAT-1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1), a long non-coding RNA (lncRNA) that plays a significant role in regulating gene expression, particularly at the transcriptional and post-transcriptional levels. MALAT-1 is highly conserved across species and is involved in processes such as RNA splicing, gene transcription, and the regulation of alternative splicing events. It localizes primarily to nuclear speckles, where it interacts with pre-mRNA processing factors and influences RNA metabolism. By inhibiting MALAT-1, researchers can disrupt its function, providing insight into how this lncRNA contributes to the regulation of gene expression, splicing mechanisms, and the maintenance of RNA stability in various cellular contexts.
In research, MALAT-1 inhibitors serve as crucial tools for studying the functional roles of long non-coding RNAs in cellular processes. By blocking MALAT-1 activity, scientists can investigate its impact on the expression and processing of specific genes, as well as its role in the formation and function of nuclear speckles. Inhibition of MALAT-1 allows researchers to explore how this lncRNA influences alternative splicing decisions, thereby impacting the diversity of proteins produced within a cell. Additionally, MALAT-1 inhibitors provide insights into the interactions between MALAT-1 and other components of the RNA processing machinery, offering a deeper understanding of how long non-coding RNAs regulate gene expression at multiple levels. These studies contribute to a broader knowledge of the molecular mechanisms controlling RNA processing and the complex regulatory networks that govern gene expression and cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A could potentially decrease MALAT-1 transcription by altering the epigenetic landscape, particularly by inducing changes in DNA methylation and histone acetylation patterns in the promoter region of the MALAT-1 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog that can incorporate into DNA and RNA, resulting in the hypomethylation of gene regulatory regions; this may lead to the repression of MALAT-1 expression in cancer cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may downregulate MALAT-1 expression by interfering with the transcriptional machinery directly at the MALAT-1 gene locus, potentially through the stabilization of repressive histone marks. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid might repress MALAT-1 by binding to its retinoic acid response elements, leading to the recruitment of co-repressor complexes at the MALAT-1 promoter. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin could reduce MALAT-1 expression by inhibiting the activation of transcriptional activators or the binding of essential transcription factors to the MALAT-1 promoter region. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may diminish MALAT-1 expression by attenuating the activity of the mTOR pathway, which is involved in the transcriptional control of several lncRNAs, including MALAT-1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A could lead to the downregulation of MALAT-1 by preventing the removal of acetyl groups from histones, thus maintaining a chromatin structure unfavorable for MALAT-1 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane might repress MALAT-1 expression by directly inhibiting the binding of transcription factors known to enhance MALAT-1 transcription or by altering the local chromatin structure at the MALAT-1 locus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could inhibit MALAT-1 expression by hindering the recruitment of transcriptional machinery to the MALAT-1 promoter, possibly through the alteration of promoter accessibility. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate may reduce MALAT-1 expression by increasing histone acetylation levels, thereby facilitating the binding of transcriptional repressors or hindering the binding of transcriptional enhancers at the MALAT-1 promoter. | ||||||