Magmas Activators
Magmas activators encompass a variety of chemical compounds that indirectly enhance the functional activity of Magmas through discrete biochemical pathways. Forskolin, Isoproterenol, Zaprinast, and Rolipram elevate intracellular cAMP, leading to the activation of PKA. PKA then potentially phosphorylates proteins that directly or indirectly interact with Magmas, thereby amplifying its activity within mitochondrial import processes. Similarly, compounds like Epigallocatechin gallate (EGCG) and the PI3K inhibitor LY294002 can shift cellular signaling dynamics away from competing pathways, which may result in the enhancement of Magmas's role in mitochondrial function. The alterations in signaling pathways by U0126 and SB203580, which inhibit MEK1/2 and p38 MAPK respectively, may also lead to changes in protein interactions that favor the upregulation of Magmas activity.
Additionally, lipid signaling modifications induced by compounds such as Sphingosine-1-phosphate and the PKC activator Phorbol 12-myristate 13-acetate (PMA) might influence Magmas's activity by modulating mitochondrial-associated processes. The calcium ionophores Ionomycin and A23187 are known to raise intracellular calcium levels, which can activate calcium-dependent kinases and proteins that impact the function of Magmas.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can subsequently activate PKA. PKA phosphorylation targets may include proteins that interact with Magmas, leading to its enhanced functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which may phosphorylate substrates that interact with or modulate the function of Magmas, indirectly enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can activate sphingosine-1-phosphate receptors and downstream signaling pathways, potentially influencing mitochondrial processes in which Magmas plays a role. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, activating calcium-dependent protein kinases that could enhance the activity of Magmas by modulating its mitochondrial import activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
As a beta-adrenergic agonist, isoproterenol increases cAMP in the cell, which can activate PKA and could lead to phosphorylation events enhancing Magmas activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that can modulate cellular pathways by inhibiting kinases that may compete with signaling pathways involving Magmas, thereby potentially enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that might shift cellular signaling towards pathways that involve Magmas, enhancing its mitochondrial function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This p38 MAPK inhibitor can modify signaling pathways, potentially leading to changes in mitochondrial dynamics where Magmas is involved, enhancing its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, thus might activate signaling pathways that enhance the activity of Magmas. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5, leading to increased cAMP levels in the cell, which could enhance PKA activity and indirectly enhance Magmas activity. | ||||||