Magmas Inhibitors
Chemical inhibitors of Magmas can be utilized to hinder its function by disrupting the mitochondrial ATP production upon which it is reliant. Compounds such as Oligomycin A and Aurovertin B target the mitochondrial ATP synthase directly, leading to a diminished availability of ATP. Without adequate ATP, Magmas cannot maintain its role in mitochondrial protein import, as it utilizes ATP for its operation within the mitochondria. Similarly, Antimycin A and Myxothiazol obstruct mitochondrial complex III, while Carboxin, Thenoyltrifluoroacetone (TTFA), and Rotenone target complexes II and I, respectively. By interfering with various components of the electron transport chain, these inhibitors contribute to a decrease in ATP synthesis. The reduced production of ATP consequent to the inhibition of these complexes directly diminishes the functional activity of Magmas, as it cannot perform effectively without a steady supply of ATP.
Furthermore, chemicals like Azide and Stigmatellin also inhibit complexes within the electron transport chain, such as complex IV and III, leading to a similar reduction in ATP synthesis and subsequent functional inhibition of Magmas. The action of Malonate as a competitive inhibitor of succinate dehydrogenase impedes the tricarboxylic acid cycle, contributing to the reduced production of electron donors for the electron transport chain, thereby limiting ATP production and inhibiting Magmas. Additionally, FCCP acts as an uncoupler of oxidative phosphorylation, dissipating the proton gradient across the mitochondrial membrane, which is essential for ATP synthesis. This disruption further leads to a decrease in ATP levels, impeding Magmas activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A inhibits the mitochondrial ATP synthase, leading to a reduction in ATP levels. Magmas, being involved in mitochondrial protein import, is reliant on ATP for its function. Inhibition of ATP synthesis by Oligomycin A can therefore lead to functional inhibition of Magmas. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits mitochondrial complex III, which is part of the electron transport chain, resulting in decreased ATP production. Reduced ATP availability can inhibit Magmas function, as Magmas is ATP-dependent for its chaperone activity in mitochondrial protein import. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits mitochondrial complex II, leading to decreased ATP production. Since Magmas relies on ATP to perform its role in mitochondrial protein import, inhibition of ATP production by Carboxin can functionally inhibit Magmas activity. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
Thenoyltrifluoroacetone (TTFA) inhibits mitochondrial complex II. This inhibition disrupts the electron transport chain, thereby reducing ATP synthesis. As Magmas requires ATP for its function, the reduction in ATP levels due to TTFA can lead to the functional inhibition of Magmas. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aurovertin B inhibits mitochondrial ATP synthase, thereby decreasing ATP production. As Magmas activity is dependent on ATP, the reduction in ATP levels due to Aurovertin B can lead to functional inhibition of Magmas. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Azide inhibits mitochondrial complex IV, which impacts ATP synthesis. The resulting decrease in ATP levels can inhibit Magmas, as Magmas requires ATP for its activity in mitochondrial protein import. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits mitochondrial complex I, leading to a decrease in ATP production. Magmas, being ATP-dependent for its role in mitochondrial protein import, can be functionally inhibited by the reduction in ATP levels due to Rotenone. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Piericidin A is a complex I inhibitor, reducing ATP synthesis in mitochondria. Magmas is dependent on mitochondrial ATP for its protein import function, thus inhibition of ATP production by Piericidin A can lead to functional inhibition of Magmas. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP uncouples oxidative phosphorylation, disrupting ATP synthesis. The subsequent reduction in ATP levels can lead to functional inhibition of Magmas, which requires ATP for its role in mitochondrial protein import. | ||||||
Myxothiazol | 76706-55-3 | sc-507550 | 1 mg | $145.00 | ||
Myxothiazol targets mitochondrial complex III, reducing ATP production. As Magmas is ATP-dependent, the inhibition of ATP synthesis by Myxothiazol can functionally inhibit Magmas. | ||||||