Ly-55B Activators
Ly-55B, known scientifically as Klrb1b in Mus musculus (house mouse), represents a critical component in the immunological arsenal of natural killer (NK) cells, functioning predominantly within the innate immune system. This protein is characterized by its ability to bind identically structured proteins, thereby playing a pivotal role in the regulation of NK cell-mediated cytotoxic activities. The significance of Ly-55B extends to its structural location on the external side of the plasma membrane, where it is recognized as an integral component. Through its signaling receptor activity, Ly-55B acts upstream of or within processes leading to the negative regulation of NK cell-mediated cytotoxicity. The orthologous human counterpart of this receptor is known as KLRB1, indicating a conserved function across species in the context of immune regulation. The primary function of Ly-55B involves the facilitation of immune surveillance and the prompt response to aberrant cellular presences, underscoring its role in the first line of defense against malignancies and virally infected cells.
The mechanism of activation for Ly-55B involves a complex interplay of cellular signaling pathways that enhance its capacity to regulate NK cell functions effectively. This activation process is intricately tied to the receptor's ability to recognize and bind to specific ligands presented on the surface of target cells, a fundamental aspect that dictates the subsequent immune response. Upon ligand binding, Ly-55B undergoes conformational changes that trigger intracellular signaling cascades, culminating in the modulation of NK cell activity. These signaling pathways often involve the recruitment and activation of downstream signaling molecules and kinases that collectively work to fine-tune the cytotoxic response of NK cells. Specifically, the activation of Ly-55B is linked to the orchestration of cytoskeletal rearrangements and the mobilization of cytolytic granules towards the immunological synapse, a critical step in the directed release of effector molecules. Furthermore, the receptor's engagement influences the expression of key regulatory genes involved in NK cell activation, proliferation, and survival, thereby modulating the immune response at multiple levels. Through these multifaceted signaling networks, Ly-55B exerts a profound influence on the operational dynamics of NK cells, enabling a robust and coordinated immune response to pathological challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid activates the SIRT1 pathway, which then leads to the upregulation of the FOXO3a pathway. Ly-55B, which operates within the FOXO3a pathway, has its functional activity enhanced with this activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, activates the SIRT1 pathway. This in turn leads to the activation of the FOXO3a pathway, enhancing the functional activity of Ly-55B, a protein involved in this pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid compound, activates the PI3K/Akt pathway. This activation indirectly leads to the upregulation of the FOXO3a pathway, where Ly-55B operates, thus enhancing its functional activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates the AMPK pathway, which subsequently leads to the activation of the FOXO3a pathway. This activation enhances the functional activity of Ly-55B, a protein that functions within this pathway. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin, an AMPK activator, enhances the activity of the AMPK pathway. This activation leads to the upregulation of the FOXO3a pathway, where Ly-55B operates, enhancing its functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound, inhibits the NF-kB pathway, leading to the indirect activation of the FOXO3a pathway. This activation enhances the functional activity of Ly-55B, a protein that operates within this pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin, inhibits the NF-kB pathway, leading to the indirect activation of the FOXO3a pathway. This activation enhances the functional activity of Ly-55B, a protein that operates within this pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which indirectly leads to the activation of the FOXO3a pathway. Ly-55B, a protein that operates within this pathway, has its functional activity enhanced when the pathway is activated by this compound. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $37.00 $66.00 $230.00 $665.00 $1678.00 | 39 | |
Trolox, a vitamin E analogue, activates the Nrf2 pathway. This activation indirectly leads to the activation of the FOXO3a pathway, where Ly-55B operates, thus enhancing its functional activity. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine activates the ROS/JNK pathway. The activation of this pathway leads to the indirect activation of the FOXO3a pathway, which enhances the functional activity of Ly-55B, a protein that functions within this pathway. | ||||||