LRRC27 Activators
The activation of LRRC27 is a sophisticated process that can be influenced by the modulation of various cellular pathways. Compounds that increase intracellular cAMP levels exert a profound effect on this process, as elevated cAMP activates protein kinase A (PKA). The activated PKA then phosphorylates specific substrates within the cell, which could include LRRC27, thereby increasing its activity. Similarly, the activation of protein kinase C (PKC) through certain compounds also plays a pivotal role. PKC phosphorylates a range of cellular targets which may encompass LRRC27, ultimately resulting in its heightened functional state. Furthermore, the manipulation of intracellular calcium levels by certain compounds can activate calcium-dependent protein kinases, which may subsequently phosphorylate and activate LRRC27.
In addition to these pathways, the regulation of protein synthesis and stress response pathways can also influence the activity of LRRC27. Compounds that inhibit protein synthesis are known to activate stress-activated protein kinases, such as JNK, which may then target LRRC27 for activation via phosphorylation events. Moreover, the inhibition of protein phosphatases, which would normally dephosphorylate proteins, leads to a sustained phosphorylated state of proteins within the cell, potentially including LRRC27. This persistent phosphorylation state is conducive to the continuous active state of LRRC27.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator that increases intracellular cAMP levels, thereby potentially enhancing the cAMP-dependent protein kinase A (PKA) pathway which can lead to the phosphorylation and subsequent activation of LRRC27. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activator of protein kinase C (PKC) which can phosphorylate substrates that may include LRRC27, leading to its increased activity within the cell. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Calcium ionophore that elevates intracellular calcium levels, potentially activating calcium-dependent protein kinases that could phosphorylate and activate LRRC27. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
β-adrenergic agonist that stimulates adenylyl cyclase to increase cAMP levels, which in turn activates PKA, potentially leading to the activation of LRRC27 through phosphorylation pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cell-permeable cAMP analog that activates PKA, potentially leading to the phosphorylation and activation of LRRC27. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Activates adrenergic receptors, leading to increased cAMP production and PKA activation, which could then phosphorylate and activate LRRC27. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibitor of protein phosphatases PP1 and PP2A, potentially resulting in increased phosphorylation of proteins including LRRC27, leading to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-specific inhibitor of phosphodiesterases which increases cAMP levels by preventing its degradation, enhancing PKA activity, and potentially leading to the activation of LRRC27. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore that raises intracellular calcium, activating calcium-dependent kinases which may result in the activation of LRRC27. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Inhibits protein synthesis and also activates stress-activated protein kinases like JNK, which could lead to the activation of LRRC27 through phosphorylation cascades. | ||||||