LOC390031 Activators
LOC390031 utilize various biochemical pathways to modulate the protein's activity through phosphorylation, a common mechanism for regulating protein function. Forskolin and IBMX both raise intracellular cAMP levels, albeit through different mechanisms. Forskolin directly stimulates adenylate cyclase, which catalyzes the conversion of ATP to cAMP, while IBMX inhibits phosphodiesterases, preventing cAMP degradation. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate LOC390031, leading to its activation. Epinephrine, through its interaction with adrenergic receptors, can also elevate cAMP levels or trigger calcium signaling pathways, both of which can activate kinases capable of phosphorylating LOC390031. Dibutyryl-cAMP, as a cAMP analog, bypasses upstream signaling and directly activates PKA, which, in turn, can phosphorylate and activate LOC390031.
Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1 engage with protein kinase C (PKC), a family of enzymes influential in numerous cellular processes. Activation of PKC by these agents can lead to the phosphorylation of LOC390031 if it is a substrate of PKC. Ionomycin raises intracellular calcium levels, which can activate calcium-dependent kinases that may also target LOC390031 for phosphorylation. Anisomycin, although primarily an inhibitor of protein synthesis, activates stress-activated protein kinases like JNK, which could phosphorylate LOC390031. Zinc Pyrithione's influence on MAPK signaling pathways may also result in the phosphorylation of LOC390031. Moreover, the inhibition of protein phosphatases PP1 and PP2A by Calyculin A and Okadaic Acid, respectively, prevents the removal of phosphate groups from proteins, thereby maintaining LOC390031 in a phosphorylated, active state. Sodium Orthovanadate acts similarly by inhibiting protein tyrosine phosphatases, which would also contribute to the persistence of phosphorylated LOC390031. These diverse chemicals, by modulating different kinases or phosphatases, converge on the common endpoint of modifying LOC390031 activity through phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, leading to increased cAMP levels by preventing its breakdown. Similar to Forskolin, increased cAMP activates PKA, which may phosphorylate and activate LOC390031. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates Protein Kinase C (PKC), which can phosphorylate a vast array of proteins. If LOC390031 is a PKC substrate, PMA would promote its activation through phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels. Elevated calcium can activate calcium-dependent kinases like CaMKII, which may phosphorylate and activate LOC390031 if it is a substrate. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, which can lead to the activation of cAMP-dependent pathways or calcium mobilization, both of which can lead to the activation of kinases that may phosphorylate and activate LOC390031. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor, but it also activates stress-activated protein kinases (SAPKs) like JNK. JNK activation can lead to the phosphorylation and activation of various proteins including LOC390031 if it is a substrate. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which prevents dephosphorylation of proteins. Its action can result in the sustained activation of proteins like LOC390031 by maintaining their phosphorylated state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting dephosphorylation, it can indirectly maintain the activated state of LOC390031 if it is regulated by phosphorylation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione can modulate ion channel activity and may also influence MAPK signaling pathways. Through activation of MAPKs, it could lead to phosphorylation and activation of LOC390031. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate is an inhibitor of protein tyrosine phosphatases. By preventing dephosphorylation, this chemical can lead to an increase in the phosphorylated and activated form of tyrosine-phosphorylated proteins like LOC390031. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 binds to and modulates protein kinase C. This modulation can result in the activation of downstream signaling pathways that include the phosphorylation and activation of proteins such as LOC390031. | ||||||