LOC130951 Inhibitors
PI3K inhibitors such as Wortmannin and LY294002 intercept critical cell survival and proliferation signals, thereby altering the activity of proteins like LOC130951 that may operate within those pathways. Similarly, by targeting MEK1/2, U0126 suppresses ERK pathway activity, which is pivotal in regulating various proteins, potentially including LOC130951. The inhibition of CaMKII by KN-93 affects calcium signal transduction, a key regulator of numerous proteins, and could thus modify LOC130951's functionality. Chemicals like ZM-447439, which impedes Aurora kinase, impact cell division processes and thereby the stability and activity of proteins during this crucial cellular phase.
Inhibitors such as XAV-939 and SB431542, which act on the Wnt/β-catenin and TGF-β pathways respectively, are instrumental in shaping cell fate and differentiation, processes that LOC130951 could be implicated in. Other inhibitors like DAPT, SP600125, Y-27632, and PP2 target various aspects of cellular signaling and structure, from γ-secretase activity to JNK signaling, ROCK-mediated cytoskeletal dynamics to Src family kinases, each affecting the cellular context in which LOC130951 operates.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, affecting Akt signaling, which can alter the activity of downstream proteins that may include LOC130951. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Inhibits CaMKII, potentially affecting calcium signal transduction and the function of proteins regulated by calcium, including LOC130951. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
Inhibits Aurora kinase, which can affect cell cycle progression and thus the stability and activity of LOC130951 during cell division. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Inhibits Wnt/β-catenin signaling by stabilizing Axin, which can affect the expression and function of proteins such as LOC130951. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
Inhibits FGFR, which can affect cell growth and differentiation pathways, potentially altering the role of LOC130951 in these processes. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Inhibits γ-secretase, affecting Notch signaling, which can modify the expression and activity of proteins including LOC130951. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which can impact apoptosis and transcription factors that regulate proteins like LOC130951. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits TGF-β receptor, which can affect cellular processes like differentiation, potentially impacting LOC130951's function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK, affecting cytoskeletal organization and cell motility, which can influence the function or localization of LOC130951. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Inhibits Src family kinases, which can alter cell adhesion, growth, and survival, potentially affecting LOC130951's activity. | ||||||