LIR-7 Inhibitors
Chemical inhibitors of LIR-7 employ a variety of mechanisms to modulate the activity of this immune-related protein. Methyl salicylate, for example, inhibits the cyclooxygenase enzymes, leading to a reduction in prostaglandin synthesis which can suppress the activation of LIR-7. Similarly, celecoxib, a selective COX-2 inhibitor, operates by diminishing the production of pro-inflammatory prostaglandins thereby regulating the immune response associated with LIR-7 activity. Apigenin takes a different approach, acting as a tyrosine kinase inhibitor which can interfere with the phosphorylation processes essential for the activation of LIR-7. Zileuton contributes to the inhibition by targeting the 5-lipoxygenase pathway, reducing leukotriene production, which is vital in the immune response cascade that can activate LIR-7.
Other inhibitors like parthenolide and resveratrol target the NF-κB pathway, a central regulator of immune response genes, thus modulating the protein expression levels that would otherwise engage LIR-7. Curcumin also targets NF-κB, along with downregulating inflammatory cytokines, which collectively can influence LIR-7 activity. Flavonoids such as wogonin and quercetin exhibit their inhibitory effect through different mechanisms; wogonin modulates STAT3 activity, an important player in cytokine signaling, while quercetin stabilizes mast cells, reducing histamine release and inhibiting the PI3K/Akt pathway. Additionally, epigallocatechin gallate inhibits the activity of DNA methyltransferases which can lead to decreased methylation of DNA regions controlling pro-inflammatory genes, consequently affecting LIR-7 signaling. Piperine disrupts enzyme functions and transcription factors including NF-κB, which regulates gene expression related to LIR-7 activity. Lastly, sulfasalazine inhibits NF-κB and the release of inflammatory mediators from immune cells, contributing to the regulation of immune responses involving LIR-7.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate inhibits LIR-7 by acting as an inhibitor of cyclooxygenases (COX), which are involved in the production of inflammatory mediators that could upregulate LIR-7 activity. By reducing prostaglandin synthesis, methyl salicylate decreases the inflammatory response, potentially diminishing LIR-7 mediated immune cell activation. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin inhibits LIR-7 through its action as a tyrosine kinase inhibitor. Since tyrosine kinases are involved in the activation of immune responses that may include LIR-7 signaling, apigenin can hinder the phosphorylation events that would otherwise contribute to LIR-7 activation. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton functions as a 5-lipoxygenase inhibitor and could inhibit LIR-7 by reducing leukotriene synthesis, which plays a role in inflammatory responses that can enhance LIR-7 activity. By curtailing leukotriene production, zileuton can suppress immune cell recruitment and activation associated with LIR-7. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits LIR-7 by blocking nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Since NF-κB is a transcription factor that can regulate immune response genes potentially tied to LIR-7 activity, parthenolide's inhibition of NF-κB can reduce the expression of proteins involved in the activation of LIR-7. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol suppresses the activation of LIR-7 by inhibiting the NF-κB pathway, which is implicated in the regulation of immune responses that may involve LIR-7. By preventing NF-κB from translocating to the nucleus, resveratrol can diminish the expression of inflammatory genes that would otherwise contribute to LIR-7 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin inhibits LIR-7 function by impeding the activation of the NF-κB pathway and downregulating the expression of inflammatory cytokines that can enhance LIR-7 signaling. Its broad anti-inflammatory properties help reduce the overall immune activation that involves LIR-7. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin, a flavonoid derived from Scutellaria baicalensis, can inhibit LIR-7 by modulating the activity of signal transducer and activator of transcription 3 (STAT3), which is involved in cytokine signaling that may upregulate LIR-7 activity. By inhibiting STAT3, wogonin can decrease cytokine-induced LIR-7 activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) from green tea inhibits LIR-7 by inhibiting the enzymatic activity of DNA methyltransferases (DNMTs), potentially leading to hypomethylation of DNA regions that control the expression of pro-inflammatory genes involved in LIR-7 signaling. This can attenuate the inflammatory responses associated with LIR-7. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine can inhibit LIR-7 by interfering with the activity of certain enzymes and transcription factors, such as NF-κB, that regulate the immune response. This interference can reduce the expression of genes that would otherwise support the inflammatory environment which enhances LIR-7 activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits LIR-7 by stabilizing mast cells and reducing the release of histamine and other pro-inflammatory mediators that can lead to the activation of LIR-7. It also inhibits the PI3K/Akt pathway, which could be involved in LIR-7 mediated signaling. | ||||||