Molecular structure of Zileuton, CAS Number: 111406-87-2
Zileuton (CAS 111406-87-2)
See product citations (8)
Application:
Zileuton is a 5-LO (5-lipoxygenase) inhibitor
CAS Number:
111406-87-2
Purity:
>99%
Molecular Weight:
236.29
Molecular Formula:
C11H12N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zileuton functions as a leukotriene antagonist, which means it inhibits the effects of leukotrienes, compounds that contribute to cellular inflammation. Research has shown that zileuton can decrease the production of leukotrienes, which has research impacts in the context of inflammation and airway constriction. Laboratory studies across various cell culture systems have corroborated its ability to suppress leukotriene activity. Furthermore, it has been noted to hinder the proliferation of certain cancer cell lines in controlled lab settings. The mechanism of zileuton′s action relates to its ability to attach to leukotriene receptors, blocking these inflammatory mediators from interacting with their targets.
Zileuton (CAS 111406-87-2) References
- Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. | McMillan, RM., et al. 1992. Br J Pharmacol. 107: 1042-7. PMID: 1334748
- Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. | Lu, P., et al. 2003. Drug Metab Dispos. 31: 1352-60. PMID: 14570767
- The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor. | Bell, RL., et al. 1992. Int J Immunopharmacol. 14: 505-10. PMID: 1618602
- Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats. | Tu, XK., et al. 2010. Inflammation. 33: 344-52. PMID: 20204486
- Zileuton alleviates acute cisplatin nephrotoxicity: Inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis. | Helmy, MM., et al. 2018. Prostaglandins Other Lipid Mediat. 135: 1-10. PMID: 29355720
- Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway. | Khophai, S., et al. 2018. Onco Targets Ther. 11: 7019-7029. PMID: 30410359
- Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation. | Lim, HJ., et al. 2019. Cells. 8: PMID: 31575085
- The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα. | Wu, QQ., et al. 2019. Oxid Med Cell Longev. 2019: 7536803. PMID: 31781348
- Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress. | Liu, CH., et al. 2020. Int Immunopharmacol. 78: 105947. PMID: 31796384
- Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach. | Kubick, N., et al. 2020. Molecules. 25: PMID: 32380663
- Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models. | Li, L., et al. 2021. Cancer Chemother Pharmacol. 88: 953-960. PMID: 34477945
- Treatment with the 5-Lipoxygenase Antagonist Zileuton Protects Mice from Postoperative Ileus. | Enderes, J., et al. 2022. Eur Surg Res. 63: 224-231. PMID: 35184063
- Zileuton Alleviates Radiation-Induced Cutaneous Ulcers via Inhibition of Senescence-Associated Secretory Phenotype in Rodents. | Park, M., et al. 2022. Int J Mol Sci. 23: PMID: 35955523
- Evidence for an ionic binding of lipoprotein lipase to heparin. | Olivecrona, T., et al. 1971. Biochem Biophys Res Commun. 43: 524-9. PMID: 5563304
- The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. | Malo, PE., et al. 1994. Pulm Pharmacol. 7: 73-9. PMID: 8081074
Inhibitor of:
12-LO, 15-LO, 15-LO2, 5-LO, AADACL4, ABCB7, ADO, Alox12e, ALOXE3, CCL (C-C motif chemokine ligand), CD16-A, COTL1, CYP1A2, CYP2J13, CYP4A12A, Cyp4f14, Cyp4f15, CYP4F3, cytohesin-4, DHRS11, ECP, EG668526, FLAP, GCP-2, GDF8, Gm885, Granulocyte Marker, Granulocytee Marker, HRASLS2, HRSP12, IFN-α4, IgE, IL-13, IL-18Rβ, IL-1F7, Il-28a, IL-5R, LF, LGALS9, Lipocalin-6, LIR-7, LOC100041282, LOC646823, LOX, LOXHD1, LT-β, MAGE-6, Mast Cell Protease 7, MCP-4, Mitoferrin, MPST, NARFL, p22-phox, PECR, Peroxin 1, PXDN, Reg ll, SerpinB9e, Siglec-8, SULT1A3, TMEM164, Tryptase, UGRP1, and UGRP2.Activator of:
AKR1B7, Alox12e, Blr1, BPI, Cyp2c38, Cyp2c39, Cyp4f13, CysLT1, CysLT1 Receptor, EPX, Fc ε RIβ, G-CSFR, IQCF1, LTA4H, LTB4DH, LTB4R2, NYD-SP29, OATP-H, PGD2 synthase, and T Neutrophil.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zileuton, 10 mg | sc-204417 | 10 mg | $84.00 | |||
Zileuton, 50 mg | sc-204417A | 50 mg | $307.00 | |||
Zileuton, 1 g | sc-204417B | 1 g | $369.00 | |||
Zileuton, 75 g | sc-204417C | 75 g | $1254.00 |