Liprin α4 Activators
Liprin α4 is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family, which plays a crucial role in the regulation of cellular processes such as cell adhesion, mobility, and particularly in the development and maintenance of neuronal synapses. Liprin α4 is predominantly expressed in the nervous system where it orchestrates the assembly of presynaptic active zones and influences synaptic vesicle recycling, thereby contributing to the fine-tuning of synaptic transmission and plasticity. The protein is involved in the intricate network of signaling pathways that underpin neurodevelopment and cognitive functions. Given its pivotal position in the synaptic architecture, the expression levels of Liprin α4 are tightly regulated by a variety of intracellular signaling cascades, and its expression can be modulated by several chemical compounds, which do so by engaging with different molecular pathways.
Exploring the activators of Liprin α4 expression, various small molecules and chemical compounds have been identified that could potentially serve as upregulators of this protein. For instance, retinoic acid, a metabolite of vitamin A, is well-documented for its role in neural differentiation and could potentially induce Liprin α4 expression by enhancing gene transcription during brain development. Similarly, forskolin, known to elevate intracellular cAMP levels, may stimulate Liprin α4 production through activation of cAMP response element-binding proteins (CREBs), which can initiate transcription of neuronal genes. Compounds like valproic acid, an HDAC inhibitor, may also promote Liprin α4 expression by increasing histone acetylation, which in turn makes the genomic regions of interest more accessible for transcriptional machinery. Furthermore, cyclic AMP analogs such as dibutyryl-cAMP could directly induce Liprin α4 expression by mimicking the action of endogenous cAMP, thereby activating protein kinase A (PKA) and other factors involved in transcriptional regulation. These activators, by interfacing with the cell's endogenous machinery, could potentially elevate the levels of Liprin α4, highlighting the intricate web of molecular interactions that govern synaptic protein expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could upregulate Liprin α4 expression by stimulating gene transcription during the maturation of neurons, particularly in brain development, where Liprin α4 is known to be expressed. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin may increase Liprin α4 transcription through the activation of cAMP response element-binding protein (CREB), which in turn could bind to the promoter region of the Liprin α4 gene, leading to its upregulation. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
As a kinase inhibitor, K-252a might indirectly stimulate Liprin α4 expression by inhibiting negative regulatory kinases that typically suppress neurotrophic signaling pathways linked to synaptic growth and development. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, by inhibiting phosphodiesterase-4 (PDE4) and thereby elevating intracellular cAMP levels, could lead to an increase in Liprin α4 expression as part of the downstream synaptic protein expression cascade. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may stimulate Liprin α4 expression by upregulating transcription factors associated with neuronal growth and differentiation, given its broad effects on gene expression related to neuroprotection and synaptic plasticity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Exogenous Adenosine 3',5'-cyclic monophosphate could directly increase Liprin α4 expression by serving as a second messenger in signaling pathways that stimulate the transcription of genes involved in synapse formation and maintenance. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, through its action as an HDAC inhibitor, might upregulate Liprin α4 by increasing the acetylation of histones, thereby uncoiling DNA and making the Liprin α4 gene more accessible for transcription. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $318.00 | 9 | |
Fluoxetine may stimulate Liprin α4 expression as part of its broader role in neurogenesis and neural plasticity, potentially by enhancing serotonergic signaling which is implicated in neurodevelopmental processes. | ||||||
N6-Cyclopentyladenosine | 41552-82-3 | sc-204117 | 50 mg | $120.00 | 2 | |
N6-Cyclopentyladenosine, as an adenosine A1 receptor agonist, might induce Liprin α4 expression by activating intracellular signaling cascades that promote neuronal maturation and synaptic protein expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol may increase Liprin α4 expression by engaging beta-adrenergic receptors, leading to downstream signaling events that culminate in the transcriptional activation of genes related to synaptic function. | ||||||