Molecular structure of Fluoxetine, CAS Number: 54910-89-3
Fluoxetine (CAS 54910-89-3)
See product citations (9)
Alternate Names:
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
Application:
Fluoxetine is a 5-hydroxytryptamine reuptake inhibitor
CAS Number:
54910-89-3
Molecular Weight:
309.33
Molecular Formula:
C17H18F3NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluoxetine is a 5-hydroxytryptamine (serotonin, 5-HT) reuptake inhibitor. This compound is a racemic mixture and both R and S enantiomers are reported to inhibit 5-HT uptake in synaptosomal preparations of rat cerebral cortex. Fluoxetine is also noted to be a highly selective, sodium dependent, ST (5-HT transporter) in studies of rat cerebrums. Additionally, Fluoxetine is also noted to increase extracellular levels of 5-HT in several areas of the rat brain as a result of reuptake inhibition. This increase in availability of 5-HT is reported to lead to a decrease in synthesis and turnover of 5-HT. It is also available as Fluoxetine HCl (sc-201125).
Fluoxetine (CAS 54910-89-3) References
- Fluoxetine increases GABA(A) receptor activity through a novel modulatory site. | Robinson, RT., et al. 2003. J Pharmacol Exp Ther. 304: 978-84. PMID: 12604672
- Fluoxetine in panic disorder. | Schneier, FR., et al. 1990. J Clin Psychopharmacol. 10: 119-21. PMID: 2341585
- Toxicokinetics, disposition and metabolism of fluoxetine in crabs. | Robert, A., et al. 2017. Chemosphere. 186: 958-967. PMID: 28830067
- Detecting fluoxetine and norfluoxetine in wild bird tissues and feathers. | Whitlock, SE., et al. 2019. Environ Int. 126: 193-201. PMID: 30802636
- Fluoxetine disposition and elimination in cirrhosis. | Schenker, S., et al. 1988. Clin Pharmacol Ther. 44: 353-9. PMID: 3262026
- The impact of fluoxetine and pH values on relaxation of the ternary lipid monolayers. | Xie, B., et al. 2021. Biochim Biophys Acta Biomembr. 1863: 183760. PMID: 34499884
- Fluoxetine modulates the pro-inflammatory process of IL-6, IL-1β and TNF-α levels in individuals with depression: a systematic review and meta-analysis. | García-García, ML., et al. 2022. Psychiatry Res. 307: 114317. PMID: 34864233
- Fluoxetine Treatment Decreases Cardiac Vagal Input and Alters the Serotonergic Modulation of the Parasympathetic Outflow in Diabetic Rats. | García-Domingo, M., et al. 2022. Int J Mol Sci. 23: PMID: 35628547
- Brain serotonin deficiency and fluoxetine lead to sex-specific effects on binge-like food consumption in mice. | Karth, MD., et al. 2022. Psychopharmacology (Berl). 239: 2975-2984. PMID: 35750862
- Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress - an animal model of depression. | Lam, RW., et al. 2022. Transl Psychiatry. 12: 339. PMID: 35987907
- Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling. | Rayan, NA., et al. 2022. Mol Psychiatry. 27: 4510-4525. PMID: 36056172
- Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. | Wong, DT., et al. 1995. Life Sci. 57: 411-41. PMID: 7623609
- Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. | Beck, SG., et al. 1997. J Pharmacol Exp Ther. 281: 115-22. PMID: 9103487
- Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | Owens, MJ., et al. 1997. J Pharmacol Exp Ther. 283: 1305-22. PMID: 9400006
Inhibitor of:
ASM, BC049352, C12orf62, C230078M14Rik, C8orf68, Cerebellin 3, Ces1c, CIDE-A, CLC-KB, CRY2, CYP20A1, CYP2AB1, CYP2B1, CYP2B10, CYP2B19, CYP2B23, CYP2B9, Cyp2c38, Cyp2c39, Cyp2c50, Cyp2c65, Cyp2c66, Cyp2c67, Cyp2c69, Cyp2c70, CYP2D10, CYP2D11, CYP2D22, CYP2D26, CYP2D34, CYP2D6, CYP2D9, CYP2J12, CYP2J7, CYP2J8, CYP2T4, Cyp3a11, Cyp3a16, Cyp3a41a, Cyp3a44, Cyp3a57, Cyp3a59, CYP4AA2, CYP4AA3, CYP4F11, Cyp4f13, Cyp60, DGCR2, Dysbindin 1, EG226601, EXD, Freud-1, Gm13718, Gm239, HIV-1 Nef, IMP-3, IMPA2, KCNH7, KV4.2, LAL, LEP503, MAG, MATH-1, MDMA, Mrf-2, Myo-inositol monophosphatase 1, Neuritin, Norpeg, NPAS3, NYD-SP17, Olfr666, Olfr667, Olfr821, Olr252, PC-PLD1, PC-PLD2C, PMP22, RIP15, Rit2, RORβ, RyR-1, SAPAP2, Serine racemase, SEZ6L2, Shank2, Slc6a16, SLITRK5, SMPDL3A, SorCS1, SR-1A, ST, TAAR7D, TAAR8C, Tesp2, TPH, TREK-1, Unc79, and ZNF804A.Activator of:
AANAT, AGRP, AHI1, Arc, C230078M14Rik, Calcyon, CASPR4, Cerebellin 3, CYP2D11, CYPOR, DGCR2, DISC-1, ERC2, FEV, GABAA Rγ3, GABAB R1β, Gm239, HTR3D, IMPA2, IP3KA, KCC2a, LIN-10, Liprin α4, LOC338588, LRTM1, MAP-2B, MBP-probe, MOG, Myo-inositol monophosphatase 1, NBPF16, NCDN, Neurensin-1, Neurexophilin-2, NP2, NPSF, OLIG1, PCDHA10, PCDHGA1, Pcdhgb4, PCDHGB5, PCDHGC, PMP22, PNKD, Rim4, SAPAP2, Serotonin, Shank 1, SLITRK2, SPIN2, SR-2C, SR-3A, SRPX2, SYNDIG1, TAFA3, Teneurin-1, TR4, TSHβ, and TTLL7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluoxetine, 500 mg | sc-279166 | 500 mg | $312.00 |