Liprin α4 Inhibitors
Liprin α4 inhibitors are a class of small molecules that target Liprin α4, a member of the Liprin family of scaffolding proteins. Liprin proteins are involved in the organization of cellular signaling networks, particularly in synapse formation and maintenance, as well as in cell adhesion and migration. Liprin α4 specifically plays a crucial role in the regulation of protein complexes that are essential for intracellular trafficking and signaling pathways. By inhibiting Liprin α4, these compounds can interfere with its scaffolding functions, which affects the assembly of protein complexes and alters various signaling cascades within the cell. This inhibition can lead to changes in cellular organization, migration, and overall cellular communication.
Structurally, Liprin α4 inhibitors typically interact with the protein through specific binding sites that affect its conformation and activity. The structural diversity of these inhibitors allows for a range of specificities and affinities, depending on the compound's interaction with the different domains of Liprin α4. Some inhibitors may work by preventing the protein from interacting with its partners, such as those involved in cytoskeletal dynamics or vesicular transport, while others may induce conformational changes that disrupt the protein's scaffolding capacity. These compounds are useful for probing the biological functions of Liprin α4, allowing researchers to dissect the molecular mechanisms by which Liprin α4 contributes to cellular processes such as morphogenesis, polarization, and signal transduction pathways in various cell types.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could lead to hypomethylation of the Liprin α4 gene promoter, potentially resulting in a decrease in its transcriptional activity and a subsequent reduction in protein levels. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A might inhibit histone deacetylases, leading to an increase in acetylated histones around the Liprin α4 gene. This change could create a less favorable environment for gene transcription, thereby downregulating the expression of Liprin α4. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By specifically inhibiting the mTOR pathway, Rapamycin could lead to a global reduction in cap-dependent mRNA translation, including the mRNA of Liprin α4. This would result in a lowered synthesis of the Liprin α4 protein. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Although Bortezomib is a proteasome inhibitor, its effect on proteostasis might cause a cellular stress response that could include the downregulation of certain proteins, potentially including Liprin α4, as part of a broader cellular attempt to restore homeostasis. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases which may lead to an arrest in the cell cycle. This cell cycle arrest could in turn downregulate the expression of proteins involved in cell cycle progression, potentially including Liprin α4. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and blocks the elongation phase of RNA polymerase, which could lead to a decrease in total mRNA production including that of Liprin α4, thereby reducing its protein expression. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
This splicing inhibitor might disrupt the normal splicing of pre-mRNA transcripts of the Liprin α4 gene, potentially leading to the production of non-functional mRNA or a significant decrease in mature mRNA for translation. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
This binds to the 30S subunit of bacterial ribosomes and inhibits protein synthesis by blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor site. In a research setting, it might be used to inhibit eukaryotic protein synthesis, including Liprin α4, as an off-target effect. | ||||||
Sofosbuvir | 1190307-88-0 | sc-482362 | 25 mg | $143.00 | 1 | |
Although its primary use is as an antiviral agent targeting viral RNA polymerases, Sofosbuvir could exert stress on cells that indirectly leads to the downregulation of various cellular proteins, potentially including Liprin α4, as the cell reallocates resources. | ||||||