N6-Cyclopentyladenosine CAS: 41552-82-3
MF: C15H21N5O4
MW: 335.36
A selective Adenosine A1-R agonist.

N6-Cyclopentyladenosine (CAS 41552-82-3)

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Application: N6-Cyclopentyladenosine is a selective Adenosine A1-R agonist
CAS Number: 41552-82-3
Purity: >99%
Molecular Weight: 335.36
Molecular Formula: C15H21N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

N6-Cyclopentyladenosine is a potent and selective Adenosine A1-R agonist (Ki values are 2.3, 790 and 43 nM for Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R, respectively; EC50 = 18600 nM for human Adenosine A2B-R).


References

1. Klotz, K.N. 2000. Naunyn-Schmied. Arch. Pharmacol. 362: 382-391. PMID: 11111832

Physical State :
Solid
Solubility :
Soluble in 1eq. HCl (100 mM), water (1.7 mg/ml), DMSO (100 mM), methanol (19.60 - 20.40 mg/ml), and ethanol (25 mM, with warming).
Storage :
Store at 4° C
Boiling Point :
~673.4° C at 760 mmHg (Predicted)
Density :
~1.8 g/cm3 (Predicted)
Refractive Index :
n20D 1.82 (Predicted)
IC50 :
Adenosine A1 receptor: IC50 = 0.35 nM (rat); Cavia porcellus: IC50 = 0.6 nM; Adenosine A1-R: IC50 = 2.7 nM (human); Rattus norvegicus: IC50 = 10 nM; Adenosine A2 receptor: IC50 = 1.16 µM (rat)
Ki Data :
Adenosine A1 receptor: Ki= 0.3 nM (bovine); Adenosine A1 receptor: Ki= 0.3 nM (rat); Adenosine A1-R: Ki= 0.32 nM (human); human A1 receptor: Ki= 2.3 nM; human A3 receptor: Ki= 43 nM
pK Values :
pKa: 13.12 (Predicted), pKb: 3.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
657378
MDL Number :
MFCD00036845
SMILES :
C1CCC(C1)NC2=NC=NC3=C2N=CN3[[email protected]]4[[email protected]@H]([[email protected]@H]([[email protected]](O4)CO)O)O

Download SDS (MSDS)

Certificate of Analysis

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