LIN-28B Inhibitors
LIN-28B inhibitors belong to a class of small molecules or compounds that specifically target the LIN-28B protein, a key regulator in various cellular processes, particularly in the context of post-transcriptional gene regulation and stem cell development. LIN-28B is a member of the LIN-28 protein family, with LIN-28A being its close homolog. These proteins are evolutionarily conserved and are predominantly known for their roles in modulating the let-7 microRNA family, which plays crucial roles in controlling cellular differentiation, proliferation, and development. LIN-28B inhibitors are designed to disrupt the activity of LIN-28B and restore the proper function of let-7 microRNAs, thereby impacting multiple cellular processes.
At the molecular level, LIN-28B inhibitors typically interact with LIN-28B through various mechanisms. They may bind to the LIN-28B protein directly, inhibiting its RNA-binding capacity or disrupting its interaction with other regulatory elements. Additionally, some inhibitors may act by promoting LIN-28B degradation, further reducing its cellular levels. By interfering with LIN-28B function, these inhibitors can potentially influence downstream signaling pathways and gene expression profiles, ultimately affecting cellular fate and behavior. Research into LIN-28B inhibitors holds promise for gaining a deeper understanding of the intricate regulatory networks governing cell differentiation and stem cell maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, has been shown to induce differentiation in various cell types, which could lead to the downregulation of LIN-28B as it is associated with undifferentiated states. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, which may result in the alteration of epigenetic marks and potentially reduce LIN-28B expression as part of global gene expression changes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and proliferation. By inhibiting mTOR, rapamycin could indirectly reduce LIN-28B expression, as LIN-28B is known to promote cell growth. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, and it has been shown to modulate various signaling pathways, potentially influencing LIN-28B expression indirectly. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural polyphenol compound with anti-inflammatory properties. It could modulate various signaling pathways, potentially leading to the downregulation of LIN-28B expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural compound found in red wine, known for its antioxidant properties. It could influence cell signaling pathways, potentially resulting in decreased LIN-28B expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It could modulate various cellular pathways, possibly leading to reduced LIN-28B expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a major component of green tea with known antioxidant properties. It could influence various signaling pathways, potentially leading to a decrease in LIN-28B expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a soy-derived isoflavone. It could modulate estrogen receptor signaling and other pathways, potentially reducing LIN-28B expression. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin affects various cellular processes. It could indirectly influence LIN-28B expression through modulation of metabolic pathways. | ||||||