LIMP III Activators
he functional activity of Lysosomal Integral Membrane Protein III (LIMP III) is intricately linked to the stability and efficiency of lysosomal processes, which are essential for cellular homeostasis, autophagy, and the degradation of misfolded proteins. Compounds such as Forskolin and Bafilomycin A1 play pivotal roles in modulating the intracellular environment, thereby indirectly influencing LIMP III's activity. Forskolin elevates cAMP levels, which can enhance lysosomal biogenesis and function, a critical aspect of LIMP III's role in maintaining lysosomal integrity. Similarly, Bafilomycin A1's inhibition of the vacuolar type H+-ATPase alters lysosomal acidification, potentially affecting LIMP III by modifying the lysosomal environment crucial for its operational efficiency. Additionally, the chemical chaperone 4-Phenylbutyrate and antioxidants like Curcumin contribute to the stabilization and proper functioning of lysosomal proteins, including LIMP III, by enhancing protein folding and reducing cellular stress, thus indirectly supporting LIMP III's structural and functional role in lysosomes.
On another front, autophagy activators such as Rapamycin and agents that modify the lysosomal membrane composition or function, like Methyl-β-cyclodextrin and U18666A, underscore the adaptability and necessity of LIMP III in lysosomal maintenance and cellular response mechanisms. Rapamycin, by promoting autophagy, indirectly benefits LIMP III's involvement in autophagic processes, highlighting the interconnectedness of LIMP III's function with cellular health and stress responses. Similarly, Methyl-β-cyclodextrin's influence on lysosomal membrane fluidity and U18666A's induction of cholesterol accumulation within lysosomes provide unique challenges and conditions for LIMP III to maintain lysosomal integrity and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, by increasing intracellular cAMP levels, indirectly enhances lysosomal function and biogenesis, potentially affecting LIMP III's activity by optimizing lysosomal pH and enzyme activity, critical for LIMP III's role in lysosomal integrity and autophagy. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Methyl-β-cyclodextrin, by extracting cholesterol from membranes, can influence lysosomal membrane composition and fluidity, potentially affecting LIMP III's function in lysosomal membrane stability and signal transduction. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1, a specific inhibitor of the vacuolar type H+-ATPase, can alter lysosomal acidification. This alteration could indirectly affect LIMP III by modulating the lysosomal environment, which is crucial for its function in membrane stability and autophagy. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
4-Phenylbutyrate acts as a chemical chaperone, potentially enhancing the proper folding and trafficking of lysosomal proteins including LIMP III, indirectly supporting its stabilization and function in lysosomes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, through its anti-inflammatory and antioxidant properties, may enhance lysosomal function and stability, indirectly supporting LIMP III's role in lysosomal integrity and autophagy by reducing cellular stress and potentially stabilizing lysosomal membrane proteins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, by activating autophagy, can indirectly enhance LIMP III's functional role in autophagic processes and lysosomal biogenesis, critical for cellular homeostasis and the degradation of misfolded proteins. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine, by increasing lysosomal pH, can affect lysosomal enzyme activity and autophagy, potentially impacting LIMP III's role in lysosomal function and autophagy by altering the lysosomal environment. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P, by regulating lysosomal calcium release, could indirectly influence LIMP III's role in lysosomal signaling and membrane stability, supporting its function in cellular homeostasis and signaling. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN, a precursor in the NAD+ biosynthesis pathway, can enhance cellular metabolism and energy levels, potentially supporting lysosomal function and indirectly benefiting LIMP III's role in lysosomal integrity and autophagy by improving cellular health and metabolism. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A, by inducing cholesterol accumulation in lysosomes, can mimic disorders of lysosomal storage, potentially affecting LIMP III by altering lysosomal membrane composition and function, challenging LIMP III to maintain lysosomal integrity under stress conditions. | ||||||