LENG9 Activators
LENG9 can influence the protein's activity through various intracellular signaling pathways. Phorbol 12-myristate 13-acetate (PMA) and 12-O-Tetradecanoylphorbol-13-acetate (TPA) are both known to activate protein kinase C (PKC), which phosphorylates a wide range of substrates in the cell. The activation of PKC can lead to the phosphorylation of LENG9, thereby promoting its activity. Similarly, Forskolin, by increasing intracellular cAMP, activates PKA, which can also phosphorylate and activate LENG9 within its signaling network. Ionomycin, by raising intracellular calcium levels, instigates the activation of calmodulin-dependent kinase (CaMK), which might directly or indirectly lead to the phosphorylation and activation of LENG9. Calyculin A and Okadaic Acid, as inhibitors of protein phosphatases, increase the phosphorylation state of proteins, which can include LENG9, thereby upholding its active state by preventing dephosphorylation.
Epidermal Growth Factor (EGF) and Anisomycin, through their respective receptor activation and stress-activated pathways, can activate the MAPK/ERK and SAPK pathways, which are involved in the phosphorylation of a variety of proteins, potentially including LENG9. Insulin, through the PI3K/Akt signaling pathway, can have an extensive range of effects on cellular metabolism and protein phosphorylation, which may encompass the activation of LENG9 as part of its downstream effects. Dibutyryl-cAMP, as a cAMP analog, activates PKA, which promotes phosphorylation throughout the cell, and this could lead to the activation of LENG9. The beta-adrenergic agonist Isoproterenol increases cAMP levels, leading to PKA activation, which can initiate a cascade of phosphorylations ending in the activation of LENG9. Finally, A23187, a calcium ionophore, by increasing intracellular calcium, can activate CaMK, which in turn could phosphorylate and activate LENG9. These chemicals, through their actions on specific signaling pathways, ensure that phosphorylation events within the cell can culminate in the activation of LENG9.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a multitude of proteins, potentially leading to the activation of LENG9 through downstream phosphorylation events. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium concentration, which can activate calmodulin-dependent kinase (CaMK), possibly resulting in the phosphorylation and activation of LENG9. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin receptor activation stimulates PI3K/Akt signaling pathway, which could lead to the activation of LENG9 through downstream effects on cellular metabolism and protein phosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, leading to an increase in protein phosphorylation, potentially resulting in the activation of LENG9. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases, leading to increased phosphorylation levels within the cell, which may include the activation of LENG9. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates the stress-activated protein kinase (SAPK) pathways, which could lead to the activation of LENG9 through stress response signaling mechanisms. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium, activating CaMK and potentially leading to the activation of LENG9 through phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA, leading to phosphorylation of target proteins within the cell, which could result in the activation of LENG9. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, leading to PKA activation and subsequent phosphorylation and potential activation of LENG9. | ||||||